Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca

The medial septum/diagonal band of Broca (MS/DBB) is crucial for hippocampal theta rhythm generation (4-12 Hz). However, the mechanisms behind theta rhythmogenesis are still under debate. The MS/DBB consists, in its majority, of three neuronal populations that use acetylcholine, GABA, or glutamate a...

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Principais autores: Leão, Richardson Naves, Targino, Zé H., Colom, Luis V., Fisahn, André
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Idioma:eng
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Assuntos:
medial septum
theta rhythm
synchronization
cholinergic neuron
GABAergic neuron
glutamatergic neuron
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23134
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spelling ri-123456789-231342021-07-09T21:19:44Z Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca Leão, Richardson Naves Targino, Zé H. Colom, Luis V. Fisahn, André medial septum theta rhythm synchronization cholinergic neuron GABAergic neuron glutamatergic neuron The medial septum/diagonal band of Broca (MS/DBB) is crucial for hippocampal theta rhythm generation (4-12 Hz). However, the mechanisms behind theta rhythmogenesis are still under debate. The MS/DBB consists, in its majority, of three neuronal populations that use acetylcholine, GABA, or glutamate as neurotransmitter. While the firing patterns of septal neurons enable the MS/DBB to generate rhythmic output critical for the generation of the hippocampal theta rhythm, the ability to synchronize these action potentials is dependent on the interconnectivity between the three major MS/DBB neuronal populations, yet little is known about intraseptal connections. Here we assessed the connectivity between pairs of MS/DBB neurons with paired patch-clamp recordings. We found that glutamatergic and GABAergic neurons provide intraseptal connections and produce sizable currents in MS/DBB postsynaptic cells. We also analyzed linear and nonlinear relationships between the action potentials fired by pairs of neurons belonging to various MS/DBB neuronal populations. Our results show that while the synchrony index for action potential firing was significantly higher in pairs of GABAergic neurons, coherence of action potential firing in the theta range was similarly low in all pairs analyzed. Recurrence analysis demonstrated that individual action potentials were more recurrent in cholinergic neurons than in other cell types. Implementing sparse connectivity in a computer model of the MS/DBB network reproduced our experimental data. We conclude that the interplay between the intrinsic membrane properties of different MS/DBB neuronal populations and the connectivity among these populations underlie the ability of the MS/DBB network to critically contribute to hippocampal theta rhythmogenesis. 2017-05-26T18:12:23Z 2017-05-26T18:12:23Z 2015 article https://repositorio.ufrn.br/jspui/handle/123456789/23134 10.1152/jn.00367.2014 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic medial septum
theta rhythm
synchronization
cholinergic neuron
GABAergic neuron
glutamatergic neuron
spellingShingle medial septum
theta rhythm
synchronization
cholinergic neuron
GABAergic neuron
glutamatergic neuron
Leão, Richardson Naves
Targino, Zé H.
Colom, Luis V.
Fisahn, André
Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca
description The medial septum/diagonal band of Broca (MS/DBB) is crucial for hippocampal theta rhythm generation (4-12 Hz). However, the mechanisms behind theta rhythmogenesis are still under debate. The MS/DBB consists, in its majority, of three neuronal populations that use acetylcholine, GABA, or glutamate as neurotransmitter. While the firing patterns of septal neurons enable the MS/DBB to generate rhythmic output critical for the generation of the hippocampal theta rhythm, the ability to synchronize these action potentials is dependent on the interconnectivity between the three major MS/DBB neuronal populations, yet little is known about intraseptal connections. Here we assessed the connectivity between pairs of MS/DBB neurons with paired patch-clamp recordings. We found that glutamatergic and GABAergic neurons provide intraseptal connections and produce sizable currents in MS/DBB postsynaptic cells. We also analyzed linear and nonlinear relationships between the action potentials fired by pairs of neurons belonging to various MS/DBB neuronal populations. Our results show that while the synchrony index for action potential firing was significantly higher in pairs of GABAergic neurons, coherence of action potential firing in the theta range was similarly low in all pairs analyzed. Recurrence analysis demonstrated that individual action potentials were more recurrent in cholinergic neurons than in other cell types. Implementing sparse connectivity in a computer model of the MS/DBB network reproduced our experimental data. We conclude that the interplay between the intrinsic membrane properties of different MS/DBB neuronal populations and the connectivity among these populations underlie the ability of the MS/DBB network to critically contribute to hippocampal theta rhythmogenesis.
format article
author Leão, Richardson Naves
Targino, Zé H.
Colom, Luis V.
Fisahn, André
author_facet Leão, Richardson Naves
Targino, Zé H.
Colom, Luis V.
Fisahn, André
author_sort Leão, Richardson Naves
title Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca
title_short Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca
title_full Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca
title_fullStr Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca
title_full_unstemmed Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca
title_sort interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of broca
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23134
work_keys_str_mv AT leaorichardsonnaves interconnectionandsynchronizationofneuronalpopulationsinthemousemedialseptumdiagonalbandofbroca
AT targinozeh interconnectionandsynchronizationofneuronalpopulationsinthemousemedialseptumdiagonalbandofbroca
AT colomluisv interconnectionandsynchronizationofneuronalpopulationsinthemousemedialseptumdiagonalbandofbroca
AT fisahnandre interconnectionandsynchronizationofneuronalpopulationsinthemousemedialseptumdiagonalbandofbroca
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