Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter

Phenotypic sex differences in primates are associated with body differentiation during the early stages of life, expressed in both physiological and behavioral features. Hormones seem to play a pivotal role in creating a range of responses to meet environmental and social demands, resulting in bette...

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Principais autores: Sousa, Maria Bernardete Cordeiro de, Galvão, Ana Cecília de Menezes, Sales, Carla Jéssica Rodrigues, Castro, Dijenaide Chaves de, Galvão-Coelho, Nicole Leite Galvão-Coelho
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Idioma:eng
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stress coping
cortisol
cognition
development
non-human primate model
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23125
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spelling ri-123456789-231252017-11-04T21:47:52Z Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter Sousa, Maria Bernardete Cordeiro de Galvão, Ana Cecília de Menezes Sales, Carla Jéssica Rodrigues Castro, Dijenaide Chaves de Galvão-Coelho, Nicole Leite Galvão-Coelho stress coping cortisol cognition development non-human primate model Phenotypic sex differences in primates are associated with body differentiation during the early stages of life, expressed in both physiological and behavioral features. Hormones seem to play a pivotal role in creating a range of responses to meet environmental and social demands, resulting in better reactions to cope with challenges to survival and reproduction. Steroid hormones actively participate in neuroplasticity and steroids from both gonads and neurons seem to be involved in behavioral modulation in primates. Indirect evidence suggests the participation of sexual steroids in dimorphism of the stress response in common marmosets. This species is an important experimental model in psychiatry, and we found a dual profile for cortisol in the transition from juvenile to subadult, with females showing higher levels. Immature males and females at 6 and 9 months of age moved alone from the family group to a new cage, over a 21-day period, expressed distinct patterns of cortisol variation with respect to range and duration of response. Additional evidence showed that at 12 months of age, males and females buffered the hypothalamic-pituitary-adrenal axis during chronic stress. Moreover, chronic stressed juvenile marmoset males showed better cognitive performance in working memory tests and motivation when compared to those submitted to short-term stress living in family groups. Thus, as cortisol profile seems to be sexually dimorphic before adulthood, age and sex are critical variables to consider in approaches that require immature marmosets in their experimental protocols. Moreover, available cognitive tests should be scrutinized to allow better investigation of cognitive traits in this species. 2017-05-26T16:51:44Z 2017-05-26T16:51:44Z 2015-11-30 article https://repositorio.ufrn.br/jspui/handle/123456789/23125 10.3389/fpsyt.2015.00160 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic stress coping
cortisol
cognition
development
non-human primate model
spellingShingle stress coping
cortisol
cognition
development
non-human primate model
Sousa, Maria Bernardete Cordeiro de
Galvão, Ana Cecília de Menezes
Sales, Carla Jéssica Rodrigues
Castro, Dijenaide Chaves de
Galvão-Coelho, Nicole Leite Galvão-Coelho
Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter
description Phenotypic sex differences in primates are associated with body differentiation during the early stages of life, expressed in both physiological and behavioral features. Hormones seem to play a pivotal role in creating a range of responses to meet environmental and social demands, resulting in better reactions to cope with challenges to survival and reproduction. Steroid hormones actively participate in neuroplasticity and steroids from both gonads and neurons seem to be involved in behavioral modulation in primates. Indirect evidence suggests the participation of sexual steroids in dimorphism of the stress response in common marmosets. This species is an important experimental model in psychiatry, and we found a dual profile for cortisol in the transition from juvenile to subadult, with females showing higher levels. Immature males and females at 6 and 9 months of age moved alone from the family group to a new cage, over a 21-day period, expressed distinct patterns of cortisol variation with respect to range and duration of response. Additional evidence showed that at 12 months of age, males and females buffered the hypothalamic-pituitary-adrenal axis during chronic stress. Moreover, chronic stressed juvenile marmoset males showed better cognitive performance in working memory tests and motivation when compared to those submitted to short-term stress living in family groups. Thus, as cortisol profile seems to be sexually dimorphic before adulthood, age and sex are critical variables to consider in approaches that require immature marmosets in their experimental protocols. Moreover, available cognitive tests should be scrutinized to allow better investigation of cognitive traits in this species.
format article
author Sousa, Maria Bernardete Cordeiro de
Galvão, Ana Cecília de Menezes
Sales, Carla Jéssica Rodrigues
Castro, Dijenaide Chaves de
Galvão-Coelho, Nicole Leite Galvão-Coelho
author_facet Sousa, Maria Bernardete Cordeiro de
Galvão, Ana Cecília de Menezes
Sales, Carla Jéssica Rodrigues
Castro, Dijenaide Chaves de
Galvão-Coelho, Nicole Leite Galvão-Coelho
author_sort Sousa, Maria Bernardete Cordeiro de
title Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter
title_short Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter
title_full Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter
title_fullStr Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter
title_full_unstemmed Endocrine and Cognitive Adaptations to Cope with Stress in Immature Common Marmosets (Callithrix jacchus): Sex and Age Matter
title_sort endocrine and cognitive adaptations to cope with stress in immature common marmosets (callithrix jacchus): sex and age matter
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23125
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