A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where
The association of specific events with the context in which they occur is a fundamental feature of episodic memory. However, the underlying network mechanisms generating what–where associations are poorly understood. Recently we reported that some hippocampal principal neurons develop representat...
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ri-123456789-231152021-07-08T14:26:53Z A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where Tort, Adriano Bretanha Lopes Komorowski, Robert Kopell, Nancy Eichenbaum, Howard Hippocampal neuronal firing Episodic memory Synaptic plasticity mechanism The association of specific events with the context in which they occur is a fundamental feature of episodic memory. However, the underlying network mechanisms generating what–where associations are poorly understood. Recently we reported that some hippocampal principal neurons develop representations of specific events occurring in particular locations (item-position cells). Here, we investigate the emergence of item-position selectivity as rats learn new associations for reward and find that before the animal’s performance rises above chance in the task, neurons that will later become itemposition cells have a strong selective bias toward one of two behavioral responses, which the animal will subsequently make to that stimulus. This response bias results in an asymmetry of neural activity on correct and error trials that could drive the emergence of particular item specificities based on a simple reward-driven synaptic plasticity mechanism. 2017-05-26T14:01:17Z 2017-05-26T14:01:17Z 2011 article 1549-5485 https://repositorio.ufrn.br/jspui/handle/123456789/23115 eng Acesso Aberto application/pdf |
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RI - UFRN |
| language |
eng |
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Hippocampal neuronal firing Episodic memory Synaptic plasticity mechanism |
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Hippocampal neuronal firing Episodic memory Synaptic plasticity mechanism Tort, Adriano Bretanha Lopes Komorowski, Robert Kopell, Nancy Eichenbaum, Howard A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where |
| description |
The association of specific events with the context in which they occur is a fundamental feature of episodic memory.
However, the underlying network mechanisms generating what–where associations are poorly understood. Recently we
reported that some hippocampal principal neurons develop representations of specific events occurring in particular
locations (item-position cells). Here, we investigate the emergence of item-position selectivity as rats learn new associations
for reward and find that before the animal’s performance rises above chance in the task, neurons that will later become itemposition
cells have a strong selective bias toward one of two behavioral responses, which the animal will subsequently make
to that stimulus. This response bias results in an asymmetry of neural activity on correct and error trials that could drive the
emergence of particular item specificities based on a simple reward-driven synaptic plasticity mechanism. |
| format |
article |
| author |
Tort, Adriano Bretanha Lopes Komorowski, Robert Kopell, Nancy Eichenbaum, Howard |
| author_facet |
Tort, Adriano Bretanha Lopes Komorowski, Robert Kopell, Nancy Eichenbaum, Howard |
| author_sort |
Tort, Adriano Bretanha Lopes |
| title |
A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where |
| title_short |
A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where |
| title_full |
A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where |
| title_fullStr |
A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where |
| title_full_unstemmed |
A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where |
| title_sort |
mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where |
| publishDate |
2017 |
| url |
https://repositorio.ufrn.br/jspui/handle/123456789/23115 |
| work_keys_str_mv |
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| _version_ |
1773957785855197184 |