Pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy

The pathologically synchronized neuronal activity in temporal lobe epilepsy (TLE) can be triggered by network events that were once normal. Under normal conditions, hippocampus and medial prefrontal cortex (mPFC) work in synchrony during a variety of cognitive states. Abnormal changes in this circui...

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Principais autores:	Broggini, Ana Clara Silveira, Esteves, Ingrid Miranda, Romcy-Pereira, Rodrigo Neves, Leite, João Pereira, Leão, Richardson Naves
Formato:	article
Idioma:	eng
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Assuntos:	Ictal patterns Neurophysiology Perforant path electrical stimulation Temporal lobe epilepsy Theta synchrony
Endereço do item:	https://repositorio.ufrn.br/jspui/handle/123456789/23076
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spelling	ri-123456789-230762023-02-06T18:29:24Z Pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy Broggini, Ana Clara Silveira Esteves, Ingrid Miranda Romcy-Pereira, Rodrigo Neves Leite, João Pereira Leão, Richardson Naves Ictal patterns Neurophysiology Perforant path electrical stimulation Temporal lobe epilepsy Theta synchrony The pathologically synchronized neuronal activity in temporal lobe epilepsy (TLE) can be triggered by network events that were once normal. Under normal conditions, hippocampus and medial prefrontal cortex (mPFC) work in synchrony during a variety of cognitive states. Abnormal changes in this circuit may aid to seizure onset and also help to explain the high association of TLE with mood disorders. We used a TLE rat model generated by perforant path (PP) stimulation to understand whether synchrony between dorsal hippocampal and mPFC networks is altered shortly before a seizure episode. We recorded hippocampal and mPFC local field potentials (LFPs) of animals with spontaneous recurrent seizures (SRSs) to verify the connectivity between these regions. We showed that SRSs decrease hippocampal theta oscillations whereas coherence in theta increases over time prior to seizure onset. This increase in synchrony is accompanied by a stronger coupling between hippocampal theta and mPFC gamma oscillation. Finally, using Granger causality we showed that hippocampus/mPFC synchrony increases in the pre-ictal phase and this increase is likely to be caused by hippocampal networks. The dorsal hippocampus is not directly connected to the mPFC; however, the functional coupling in theta between these two structures rises pre-ictally. Our data indicates that the increase in synchrony between dorsal hippocampus and mPFC may be predictive of seizures and may help to elucidate the network mechanisms that lead to seizure generation. 2017-05-25T16:34:07Z 2017-05-25T16:34:07Z 2016 article https://repositorio.ufrn.br/jspui/handle/123456789/23076 10.1016/j.expneurol.2016.03.007 eng Acesso Aberto
institution	Repositório Institucional
collection	RI - UFRN
language	eng
topic	Ictal patterns Neurophysiology Perforant path electrical stimulation Temporal lobe epilepsy Theta synchrony
spellingShingle	Ictal patterns Neurophysiology Perforant path electrical stimulation Temporal lobe epilepsy Theta synchrony Broggini, Ana Clara Silveira Esteves, Ingrid Miranda Romcy-Pereira, Rodrigo Neves Leite, João Pereira Leão, Richardson Naves Pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy
description	The pathologically synchronized neuronal activity in temporal lobe epilepsy (TLE) can be triggered by network events that were once normal. Under normal conditions, hippocampus and medial prefrontal cortex (mPFC) work in synchrony during a variety of cognitive states. Abnormal changes in this circuit may aid to seizure onset and also help to explain the high association of TLE with mood disorders. We used a TLE rat model generated by perforant path (PP) stimulation to understand whether synchrony between dorsal hippocampal and mPFC networks is altered shortly before a seizure episode. We recorded hippocampal and mPFC local field potentials (LFPs) of animals with spontaneous recurrent seizures (SRSs) to verify the connectivity between these regions. We showed that SRSs decrease hippocampal theta oscillations whereas coherence in theta increases over time prior to seizure onset. This increase in synchrony is accompanied by a stronger coupling between hippocampal theta and mPFC gamma oscillation. Finally, using Granger causality we showed that hippocampus/mPFC synchrony increases in the pre-ictal phase and this increase is likely to be caused by hippocampal networks. The dorsal hippocampus is not directly connected to the mPFC; however, the functional coupling in theta between these two structures rises pre-ictally. Our data indicates that the increase in synchrony between dorsal hippocampus and mPFC may be predictive of seizures and may help to elucidate the network mechanisms that lead to seizure generation.
format	article
author	Broggini, Ana Clara Silveira Esteves, Ingrid Miranda Romcy-Pereira, Rodrigo Neves Leite, João Pereira Leão, Richardson Naves
author_facet	Broggini, Ana Clara Silveira Esteves, Ingrid Miranda Romcy-Pereira, Rodrigo Neves Leite, João Pereira Leão, Richardson Naves
author_sort	Broggini, Ana Clara Silveira
title	Pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy
title_short	Pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy
title_full	Pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy
title_fullStr	Pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy
title_full_unstemmed	Pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy
title_sort	pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy
publishDate	2017
url	https://repositorio.ufrn.br/jspui/handle/123456789/23076
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Pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy

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