Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio

In rodents, repeated exposure to unavoidable aggression followed by sustained sensory treat can lead to prolonged social aversion. The chronic social defeat stress model explores that phenomenon and it has been used as an animal model for human depression. However, some authors have questioned wheth...

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Principais autores: Henriques-Alves, Aron M., Queiroz, Claudio Marcos Teixeira de
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Idioma:eng
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Assuntos:
resident–intruder paradigm
social defeat stress
stretch-attend posture
flight
defensive behaviors
sucrose preference test
phenotyping
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23058
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spelling ri-123456789-230582021-07-08T15:32:47Z Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio Henriques-Alves, Aron M. Queiroz, Claudio Marcos Teixeira de resident–intruder paradigm social defeat stress stretch-attend posture flight defensive behaviors sucrose preference test phenotyping In rodents, repeated exposure to unavoidable aggression followed by sustained sensory treat can lead to prolonged social aversion. The chronic social defeat stress model explores that phenomenon and it has been used as an animal model for human depression. However, some authors have questioned whether confounding effects may arise as the model also boosts anxiety-related behaviors. Despite its wide acceptance, most studies extract limited information from the behavior of the defeated animal. Often, the normalized occupancy around the social stimulus, the interaction zone, is taken as an index of depression. We hypothesized that this parameter is insufficient to fully characterize the behavioral consequences of this form of stress. Using an ethological approach, we showed that repeated social defeat delayed the expression of social investigation in long (10 min) sessions of social interaction. Also, the incidence of defensive behaviors, including stretched-attend posture and high speed retreats, was significantly higher in defeated mice in comparison to controls. Interestingly, a subpopulation of defeated mice showed recurrent and non-habituating stretched-attend posture and persistent flights during the entire session. Two indexes were created based on defensive behaviors to show that only recurrent flights correlates with sucrose intake. Together, the present study corroborates the idea that this model of social stress can precipitate a myriad of behaviors not readily disentangled. We propose that long sessions (>150 s) and detailed ethological evaluation during social interaction tests are necessary to provide enough information to correctly classify defeated animals in terms of resilience and susceptibility to social defeat stress. 2017-05-24T12:46:10Z 2017-05-24T12:46:10Z 2016-02-03 article https://repositorio.ufrn.br/jspui/handle/123456789/23058 10.3389/fnbeh.2015.00364 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic resident–intruder paradigm
social defeat stress
stretch-attend posture
flight
defensive behaviors
sucrose preference test
phenotyping
spellingShingle resident–intruder paradigm
social defeat stress
stretch-attend posture
flight
defensive behaviors
sucrose preference test
phenotyping
Henriques-Alves, Aron M.
Queiroz, Claudio Marcos Teixeira de
Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio
description In rodents, repeated exposure to unavoidable aggression followed by sustained sensory treat can lead to prolonged social aversion. The chronic social defeat stress model explores that phenomenon and it has been used as an animal model for human depression. However, some authors have questioned whether confounding effects may arise as the model also boosts anxiety-related behaviors. Despite its wide acceptance, most studies extract limited information from the behavior of the defeated animal. Often, the normalized occupancy around the social stimulus, the interaction zone, is taken as an index of depression. We hypothesized that this parameter is insufficient to fully characterize the behavioral consequences of this form of stress. Using an ethological approach, we showed that repeated social defeat delayed the expression of social investigation in long (10 min) sessions of social interaction. Also, the incidence of defensive behaviors, including stretched-attend posture and high speed retreats, was significantly higher in defeated mice in comparison to controls. Interestingly, a subpopulation of defeated mice showed recurrent and non-habituating stretched-attend posture and persistent flights during the entire session. Two indexes were created based on defensive behaviors to show that only recurrent flights correlates with sucrose intake. Together, the present study corroborates the idea that this model of social stress can precipitate a myriad of behaviors not readily disentangled. We propose that long sessions (>150 s) and detailed ethological evaluation during social interaction tests are necessary to provide enough information to correctly classify defeated animals in terms of resilience and susceptibility to social defeat stress.
format article
author Henriques-Alves, Aron M.
Queiroz, Claudio Marcos Teixeira de
author_facet Henriques-Alves, Aron M.
Queiroz, Claudio Marcos Teixeira de
author_sort Henriques-Alves, Aron M.
title Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio
title_short Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio
title_full Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio
title_fullStr Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio
title_full_unstemmed Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio
title_sort ethological evaluation of the effects of social defeat stress in mice: beyond the social interaction ratio
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23058
work_keys_str_mv AT henriquesalvesaronm ethologicalevaluationoftheeffectsofsocialdefeatstressinmicebeyondthesocialinteractionratio
AT queirozclaudiomarcosteixeirade ethologicalevaluationoftheeffectsofsocialdefeatstressinmicebeyondthesocialinteractionratio
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