A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers
Gross chromosomal rearrangements (GCRs) play an important role in human diseases, including cancer. The identity of all Genome Instability Suppressing (GIS) genes is not currently known. Here multiple Saccharomyces cerevisiae GCR assays and query mutations were crossed into arrays of mutants to iden...
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ri-123456789-230502021-07-09T22:43:43Z A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers Putnam, Christopher D. Srivatsan, Anjana Nene, Rahul V. Martinez, Sandra L. Clotfelter, Sarah P. Bell, Sara N. Somach, Steven B. Souza, Jorge E.S. de Fonseca, André F. Souza, Sandro José de Kolodner, Richard D. genetic cancer Gross chromosomal rearrangements (GCRs) play an important role in human diseases, including cancer. The identity of all Genome Instability Suppressing (GIS) genes is not currently known. Here multiple Saccharomyces cerevisiae GCR assays and query mutations were crossed into arrays of mutants to identify progeny with increased GCR rates. One hundred eighty two GIS genes were identified that suppressed GCR formation. Another 438 cooperatively acting GIS genes were identified that were not GIS genes, but suppressed the increased genome instability caused by individual query mutations. Analysis of TCGA data using the human genes predicted to act in GIS pathways revealed that a minimum of 93% of ovarian and 66% of colorectal cancer cases had defects affecting one or more predicted GIS gene. These defects included loss-of-function mutations, copy-number changes associated with reduced expression, and silencing. In contrast, acute myeloid leukaemia cases did not appear to have defects affecting the predicted GIS genes. 2017-05-23T12:46:17Z 2017-05-23T12:46:17Z 2016-04-13 article https://repositorio.ufrn.br/jspui/handle/123456789/23050 10.1038/ncomms11256 eng Acesso Aberto application/pdf |
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| language |
eng |
| topic |
genetic cancer |
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genetic cancer Putnam, Christopher D. Srivatsan, Anjana Nene, Rahul V. Martinez, Sandra L. Clotfelter, Sarah P. Bell, Sara N. Somach, Steven B. Souza, Jorge E.S. de Fonseca, André F. Souza, Sandro José de Kolodner, Richard D. A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers |
| description |
Gross chromosomal rearrangements (GCRs) play an important role in human diseases, including cancer. The identity of all Genome Instability Suppressing (GIS) genes is not currently known. Here multiple Saccharomyces cerevisiae GCR assays and query mutations were crossed into arrays of mutants to identify progeny with increased GCR rates. One hundred eighty two GIS genes were identified that suppressed GCR formation. Another 438 cooperatively acting GIS genes were identified that were not GIS genes, but suppressed the increased genome instability caused by individual query mutations. Analysis of TCGA data
using the human genes predicted to act in GIS pathways revealed that a minimum of 93% of ovarian and 66% of colorectal cancer cases had defects affecting one or more predicted GIS gene. These defects included loss-of-function mutations, copy-number changes associated with reduced expression, and silencing. In contrast, acute myeloid leukaemia cases did not appear to have defects affecting the predicted GIS genes. |
| format |
article |
| author |
Putnam, Christopher D. Srivatsan, Anjana Nene, Rahul V. Martinez, Sandra L. Clotfelter, Sarah P. Bell, Sara N. Somach, Steven B. Souza, Jorge E.S. de Fonseca, André F. Souza, Sandro José de Kolodner, Richard D. |
| author_facet |
Putnam, Christopher D. Srivatsan, Anjana Nene, Rahul V. Martinez, Sandra L. Clotfelter, Sarah P. Bell, Sara N. Somach, Steven B. Souza, Jorge E.S. de Fonseca, André F. Souza, Sandro José de Kolodner, Richard D. |
| author_sort |
Putnam, Christopher D. |
| title |
A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers |
| title_short |
A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers |
| title_full |
A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers |
| title_fullStr |
A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers |
| title_full_unstemmed |
A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers |
| title_sort |
genetic network that suppresses genome rearrangements in saccharomyces cerevisiae and contains defects in cancers |
| publishDate |
2017 |
| url |
https://repositorio.ufrn.br/jspui/handle/123456789/23050 |
| work_keys_str_mv |
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