A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study

The benign peripheral nerve sheath tumours are rare lesions mainly represented by schwannoma and neurofibroma. The present work evaluated the clinical and histopathological features of schwannomas and neurofibromas of the oral cavity diagnosed in a Brazilian population. Among 9.000 cases of oral les...

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Principais autores: Nascimento, George João Ferreira do, Rocha, Danielle de Albuquerque Pires, Galvão, Hebel Cavalcanti, Costa, Antonio de Lisboa Lopes, Souza, Lelia Batista de
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Idioma:eng
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Assuntos:
Schwannoma
Neurofibroma
Benign peripheral nerve sheath tumours
Epidemiology
Oral diseases
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/22997
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spelling ri-123456789-229972021-12-09T17:29:11Z A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study Nascimento, George João Ferreira do Rocha, Danielle de Albuquerque Pires Galvão, Hebel Cavalcanti Costa, Antonio de Lisboa Lopes Souza, Lelia Batista de Schwannoma Neurofibroma Benign peripheral nerve sheath tumours Epidemiology Oral diseases The benign peripheral nerve sheath tumours are rare lesions mainly represented by schwannoma and neurofibroma. The present work evaluated the clinical and histopathological features of schwannomas and neurofibromas of the oral cavity diagnosed in a Brazilian population. Among 9.000 cases of oral lesions archived from 1970 to 2008, four schwannomas and 12 neurofibromas were identified, microscopically revised and immunohistochemically certified through a panel including monoclonal antibodies (anti-S100, vimentin, HHF-35 and desmin). From biopsy and histological sections records, clinical and histopathological data were retrieved, reviewed and statistically analysed. Predominantly, schwannomas affected non-white males (3:1), with an age and size averages of 34.7 years and 2.8 cm, respectively. Neurofibromas preferentially occurred on the gingival/alveolar ridge of white females (5:1), with 35.7-year mean age, peak of incidence between 3rd and 5th decade, and size average of 1.7 cm. (12 cases, 75%). The studied tumours exhibited more frequently as a painless, sessile and slow growth very similar to other oral lesions, but their microscopic features differed significantly. Schwannomas and neurofibromas are extremely uncommon in the oral cavity, exhibiting clinical features very similar but specific and peculiar microscopic findings that are useful in the establishment of the diagnosis, which in some particular cases must be confirmed by immunohistochemistry. 2017-05-16T13:32:05Z 2017-05-16T13:32:05Z 2011 article NASCIMENTO, G. J. F. et al. A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study. Clinical Oral Investigations, v. 15, n. p. 329-335, 2011. https://repositorio.ufrn.br/jspui/handle/123456789/22997 10.1007/s00784-010-0389-7 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic Schwannoma
Neurofibroma
Benign peripheral nerve sheath tumours
Epidemiology
Oral diseases
spellingShingle Schwannoma
Neurofibroma
Benign peripheral nerve sheath tumours
Epidemiology
Oral diseases
Nascimento, George João Ferreira do
Rocha, Danielle de Albuquerque Pires
Galvão, Hebel Cavalcanti
Costa, Antonio de Lisboa Lopes
Souza, Lelia Batista de
A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study
description The benign peripheral nerve sheath tumours are rare lesions mainly represented by schwannoma and neurofibroma. The present work evaluated the clinical and histopathological features of schwannomas and neurofibromas of the oral cavity diagnosed in a Brazilian population. Among 9.000 cases of oral lesions archived from 1970 to 2008, four schwannomas and 12 neurofibromas were identified, microscopically revised and immunohistochemically certified through a panel including monoclonal antibodies (anti-S100, vimentin, HHF-35 and desmin). From biopsy and histological sections records, clinical and histopathological data were retrieved, reviewed and statistically analysed. Predominantly, schwannomas affected non-white males (3:1), with an age and size averages of 34.7 years and 2.8 cm, respectively. Neurofibromas preferentially occurred on the gingival/alveolar ridge of white females (5:1), with 35.7-year mean age, peak of incidence between 3rd and 5th decade, and size average of 1.7 cm. (12 cases, 75%). The studied tumours exhibited more frequently as a painless, sessile and slow growth very similar to other oral lesions, but their microscopic features differed significantly. Schwannomas and neurofibromas are extremely uncommon in the oral cavity, exhibiting clinical features very similar but specific and peculiar microscopic findings that are useful in the establishment of the diagnosis, which in some particular cases must be confirmed by immunohistochemistry.
format article
author Nascimento, George João Ferreira do
Rocha, Danielle de Albuquerque Pires
Galvão, Hebel Cavalcanti
Costa, Antonio de Lisboa Lopes
Souza, Lelia Batista de
author_facet Nascimento, George João Ferreira do
Rocha, Danielle de Albuquerque Pires
Galvão, Hebel Cavalcanti
Costa, Antonio de Lisboa Lopes
Souza, Lelia Batista de
author_sort Nascimento, George João Ferreira do
title A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study
title_short A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study
title_full A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study
title_fullStr A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study
title_full_unstemmed A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study
title_sort 38-year review of oral schwannomas and neurofibromas in a brazilian population: clinical, histopathological and immunohistochemical study
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/22997
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