Correlation of beta-catenin expression and metastasis in tongue squamous cell carcinoma
PURPOSE: It has been reported that the oral squamous cell carcinoma (OSCC) in tongue shows a more infiltrative profile, aggressive clinical course and poor prognosis, which may be related to a higher metastatic potencial. The aim of the present study was to assess the expression of β-catenin in OSCC...
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ri-123456789-229102021-12-20T17:03:05Z Correlation of beta-catenin expression and metastasis in tongue squamous cell carcinoma Freitas, Roseana de Almeida Silveira, Ericka Janine Dantas da Silveira, João Paulo Borges da Silva, Fabyanne Mazutti da Amorim, Rivadávio Fernandes Batista de Carcinoma, squamous Cell Tongue Neoplasm metastasis Beta Catenin Cell Adhesion PURPOSE: It has been reported that the oral squamous cell carcinoma (OSCC) in tongue shows a more infiltrative profile, aggressive clinical course and poor prognosis, which may be related to a higher metastatic potencial. The aim of the present study was to assess the expression of β-catenin in OSCC of the tongue and its correlation with tumor metastasis. METHODS: Twenty four cases were selected and divided in two groups: metastatic group (n=12) and non-metastatic group (n=12). A semi-quantitative analysis of the β-catenin expression was performed in the invasive tumor front and cases were graded as follows: negative (score 0), positive (score +), and strongly positive (score ++). RESULTS: It was detected that 33%, 50% and 17% of the cases in metastatic group were scored 0, + and ++, respectively, and the non-metastatic group showed that 42% were scored "0", 33% scored + and 25% scored ++. Statistical analysis showed no diference between the studied groups. CONCLUSIONS: Based on these results, it can be concluded that the immunoexpression of β-catenin does not represent a valuable tool to predict metastatic potencial of OSCC in tongue. 2017-05-16T12:01:17Z 2017-05-16T12:01:17Z 2010 article FREITAS, R. A. et al. Correlation of beta-catenin expression and metastasis in tongue squamous cell carcinoma. Acta Cirúrgica Brasileira, v. 25, n. 6, p. 513-517, 2010. https://repositorio.ufrn.br/jspui/handle/123456789/22910 eng Acesso Aberto application/pdf |
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| language |
eng |
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Carcinoma, squamous Cell Tongue Neoplasm metastasis Beta Catenin Cell Adhesion |
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Carcinoma, squamous Cell Tongue Neoplasm metastasis Beta Catenin Cell Adhesion Freitas, Roseana de Almeida Silveira, Ericka Janine Dantas da Silveira, João Paulo Borges da Silva, Fabyanne Mazutti da Amorim, Rivadávio Fernandes Batista de Correlation of beta-catenin expression and metastasis in tongue squamous cell carcinoma |
| description |
PURPOSE: It has been reported that the oral squamous cell carcinoma (OSCC) in tongue shows a more infiltrative profile, aggressive clinical course and poor prognosis, which may be related to a higher metastatic potencial. The aim of the present study was to assess the expression of β-catenin in OSCC of the tongue and its correlation with tumor metastasis.
METHODS: Twenty four cases were selected and divided in two groups: metastatic group (n=12) and non-metastatic group (n=12). A semi-quantitative analysis of the β-catenin expression was performed in the invasive tumor front and cases were graded as follows: negative (score 0), positive (score +), and strongly positive (score ++).
RESULTS: It was detected that 33%, 50% and 17% of the cases in metastatic group were scored 0, + and ++, respectively, and the non-metastatic group showed that 42% were scored "0", 33% scored + and 25% scored ++. Statistical analysis showed no diference between the studied groups.
CONCLUSIONS: Based on these results, it can be concluded that the immunoexpression of β-catenin does not represent a valuable tool to predict metastatic potencial of OSCC in tongue. |
| format |
article |
| author |
Freitas, Roseana de Almeida Silveira, Ericka Janine Dantas da Silveira, João Paulo Borges da Silva, Fabyanne Mazutti da Amorim, Rivadávio Fernandes Batista de |
| author_facet |
Freitas, Roseana de Almeida Silveira, Ericka Janine Dantas da Silveira, João Paulo Borges da Silva, Fabyanne Mazutti da Amorim, Rivadávio Fernandes Batista de |
| author_sort |
Freitas, Roseana de Almeida |
| title |
Correlation of beta-catenin expression and metastasis in tongue squamous cell carcinoma |
| title_short |
Correlation of beta-catenin expression and metastasis in tongue squamous cell carcinoma |
| title_full |
Correlation of beta-catenin expression and metastasis in tongue squamous cell carcinoma |
| title_fullStr |
Correlation of beta-catenin expression and metastasis in tongue squamous cell carcinoma |
| title_full_unstemmed |
Correlation of beta-catenin expression and metastasis in tongue squamous cell carcinoma |
| title_sort |
correlation of beta-catenin expression and metastasis in tongue squamous cell carcinoma |
| publishDate |
2017 |
| url |
https://repositorio.ufrn.br/jspui/handle/123456789/22910 |
| work_keys_str_mv |
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1773959718743572480 |