Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip

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Antitumor immunity plays an important role in the development of and protection against malignancy. In general, patients with cancer are known to be immunologically compromised. The objective of this study was to evaluate local immunity in squamous cell carcinomas (SCCs) of the tongue and lower lip...

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Principais autores: Silveira, Ericka Janine Dantas da, Miguel, Marcia Cristina da Costa, Roncalli, Angelo Giuseppe, Freitas, Roseana de Almeida, Morais, Maria de Lourdes Silva Arruda, Queiroz, Lelia Maria Guedes
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Idioma:eng
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Assuntos:
Squamous cell carcinoma
Tongue
Lower lip
Immunohistochemistry
Local immune response
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/22908
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spelling ri-123456789-229082021-12-20T17:09:22Z Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip Silveira, Ericka Janine Dantas da Miguel, Marcia Cristina da Costa Roncalli, Angelo Giuseppe Freitas, Roseana de Almeida Morais, Maria de Lourdes Silva Arruda Queiroz, Lelia Maria Guedes Squamous cell carcinoma Tongue Lower lip Immunohistochemistry Local immune response Antitumor immunity plays an important role in the development of and protection against malignancy. In general, patients with cancer are known to be immunologically compromised. The objective of this study was to evaluate local immunity in squamous cell carcinomas (SCCs) of the tongue and lower lip by immunohistochemistry, using anti-CD3, -CD4, -CD8, -CD25 and -zeta antibodies. Immunoexpression at the invasive front was compared considering anatomical tumor location and metastasis. The CD4/CD8 ratio was calculated for each case and associated with the variables. CD3+, CD4+, CD8+ and CD25+ cell counts were higher in SCCs of the lower lip and anti-zeta immunostaining was more evident in non-metastatic cases. CD8+ and CD25+ cell counts were also significantly correlated with tumor location (p=0.004 and p=0.004, respectively), with the observation of a larger number of these cells in SCCs of the lower lip. The CD4/CD8 ratio showed no significant association with metastasis or anatomical location. In conclusion, the clinical behavior of the oral SCC cases studied might be partially related to the immunohistochemical profile of the inflammatory infiltrate present at the invasive front. 2017-05-16T11:59:33Z 2017-05-16T11:59:33Z 2010 article SILVEIRA, Éricka Janine Dantas et al. Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip. Experimental and Molecular Pathology (Print), v. 88, n. 1, p. 171-175, 2010. https://repositorio.ufrn.br/jspui/handle/123456789/22908 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic Squamous cell carcinoma
Tongue
Lower lip
Immunohistochemistry
Local immune response
spellingShingle Squamous cell carcinoma
Tongue
Lower lip
Immunohistochemistry
Local immune response
Silveira, Ericka Janine Dantas da
Miguel, Marcia Cristina da Costa
Roncalli, Angelo Giuseppe
Freitas, Roseana de Almeida
Morais, Maria de Lourdes Silva Arruda
Queiroz, Lelia Maria Guedes
Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
description Antitumor immunity plays an important role in the development of and protection against malignancy. In general, patients with cancer are known to be immunologically compromised. The objective of this study was to evaluate local immunity in squamous cell carcinomas (SCCs) of the tongue and lower lip by immunohistochemistry, using anti-CD3, -CD4, -CD8, -CD25 and -zeta antibodies. Immunoexpression at the invasive front was compared considering anatomical tumor location and metastasis. The CD4/CD8 ratio was calculated for each case and associated with the variables. CD3+, CD4+, CD8+ and CD25+ cell counts were higher in SCCs of the lower lip and anti-zeta immunostaining was more evident in non-metastatic cases. CD8+ and CD25+ cell counts were also significantly correlated with tumor location (p=0.004 and p=0.004, respectively), with the observation of a larger number of these cells in SCCs of the lower lip. The CD4/CD8 ratio showed no significant association with metastasis or anatomical location. In conclusion, the clinical behavior of the oral SCC cases studied might be partially related to the immunohistochemical profile of the inflammatory infiltrate present at the invasive front.
format article
author Silveira, Ericka Janine Dantas da
Miguel, Marcia Cristina da Costa
Roncalli, Angelo Giuseppe
Freitas, Roseana de Almeida
Morais, Maria de Lourdes Silva Arruda
Queiroz, Lelia Maria Guedes
author_facet Silveira, Ericka Janine Dantas da
Miguel, Marcia Cristina da Costa
Roncalli, Angelo Giuseppe
Freitas, Roseana de Almeida
Morais, Maria de Lourdes Silva Arruda
Queiroz, Lelia Maria Guedes
author_sort Silveira, Ericka Janine Dantas da
title Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
title_short Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
title_full Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
title_fullStr Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
title_full_unstemmed Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
title_sort analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/22908
work_keys_str_mv AT silveiraerickajaninedantasda analysisoflocalimmunityinsquamouscellcarcinomaofthetongueandlowerlip
AT miguelmarciacristinadacosta analysisoflocalimmunityinsquamouscellcarcinomaofthetongueandlowerlip
AT roncalliangelogiuseppe analysisoflocalimmunityinsquamouscellcarcinomaofthetongueandlowerlip
AT freitasroseanadealmeida analysisoflocalimmunityinsquamouscellcarcinomaofthetongueandlowerlip
AT moraismariadelourdessilvaarruda analysisoflocalimmunityinsquamouscellcarcinomaofthetongueandlowerlip
AT queirozleliamariaguedes analysisoflocalimmunityinsquamouscellcarcinomaofthetongueandlowerlip
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