Leaves of Licania rigida benth and Turnera subulata have an anticoagulant activity by thrombin inhibition
The use of medicinal plants for the treatment, cure and prevention of pathologies is a habit that accompanies humanity since its beginnings. Considering that Brazil presents a great biodiversity for the production of phytotherapics, it is of paramount importance the study of plants as alternative...
Na minha lista:
| Autor principal: | |
|---|---|
| Outros Autores: | |
| Formato: | Dissertação |
| Idioma: | por |
| Publicado em: |
Brasil
|
| Assuntos: | |
| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/22371 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
| Resumo: | The use of medicinal plants for the treatment, cure and prevention of pathologies is a
habit that accompanies humanity since its beginnings. Considering that Brazil presents
a great biodiversity for the production of phytotherapics, it is of paramount importance
the study of plants as alternative sources of treatment, aiming at the search for
substances that may help the drugs currently prescribed in clinical therapeutics. Over
many years, cardiovascular disease and thromboembolic disorders have been the
leading cause of death by disease in the world, being responsible for the death of
approximately 17.5 million people by the year 2012 (31% of deaths worldwide). The
coagulation system is centrally involved in the formation of venous thrombus. Currently
defined indications for anticoagulants include prophylaxis and treatment of
thromboembolism. Unfractionated heparins and low molecular heparins are used as
anticoagulant drugs. However, these compounds are accompanied by several side
effects such as thrombocytopenia and a high risk of systemic bleeding. The effect of
this problem demanded the search for new substances in order to assist prolonged
anticoagulant therapy. In this context, this study aimed to evaluate the anticoagulant
potential, toxic and hemorrhagic effects from Licania rigida Benth and Turnera subulata
leaves, species widely found in Northeast semiarid. The extracts were obtained from
ethanol (50%) with subsequent partition with solvents of increasing polarities, including
hexane and ethyl acetate.The crude extracts were obtained from ethanol (50%) and
subsequent partition with increasingly polar solvents including hexane and ethyl
acetate. The evaluation of the extracts against the coagulation system showed a
satisfactory anticoagulant activity by Activated Partial Thromboplastin Time and
Prothrombin Time (100% activity), Anti-Xa activity (~ 40% inhibition) and a large
capacity to inhibit directly from Thrombin (~ 80 to 100% inhibition) as the main
mechanism of action. In addition, the extracts were found to have a low hemorrhagic
effect, as well as the absence of toxicity in in vitro models (MTT cytotoxicity) and in
vivo (acute oral toxicity). This paper reports for the first time the anticoagulant potential
of Licania rigida Benth and Turnera subulata. |
|---|