O papel de oscilações beta2 e de interneurônios OLMα2 da região CA1 do hipocampo de camundongos na memória de reconhecimento de objetos
The hippocampus is associated to novelty detection and formation of explicit memories. The present work aims at better understanding the role of the CA1 region of the hippocampus in these processes. By employing electrophysiology, animal behavior, psychopharmacology and optogenetic techniques in...
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| Formato: | doctoralThesis |
| Idioma: | por |
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Brasil
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/22234 |
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| Resumo: | The hippocampus is associated to novelty detection and formation of explicit memories.
The present work aims at better understanding the role of the CA1 region of the
hippocampus in these processes. By employing electrophysiology, animal behavior,
psychopharmacology and optogenetic techniques in transgenic and wild-type mice, we
found that CA1 OLMα2 cells influence the formation of new object representations in an
object recognition task, as well as the encoding of aversive memories in a contextual fear
memory task. Furthermore, we characterized a new oscillatory activity in the local field
potential of CA1 at beta 2 frequency (23-30 Hz), which was typically transient and linked
to the amount of novelty in an object recognition task. These results suggest potential
cellular and network mechanisms that underlie the role of CA1 in memory formation and
novelty detection. |
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