Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer

This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was comp...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Lopes, Maria Luiza Diniz de Sousa, Oliveira, Denise Hélen Imaculada Pereira de, Sarmento, Dmitry José de Santana, Queiroz, Lelia Maria Guedes, Miguel, Marcia Cristina da Costa, Silveira, Ericka Janine Dantas da
Formato: article
Idioma:eng
Publicado em:
Assuntos:
Actinic cheilitis
Squamous cell carcinoma
Lip carcinogenesis
Oral cancer
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/21849
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id ri-123456789-21849
record_format dspace
spelling ri-123456789-218492021-12-20T18:00:03Z Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer Lopes, Maria Luiza Diniz de Sousa Oliveira, Denise Hélen Imaculada Pereira de Sarmento, Dmitry José de Santana Queiroz, Lelia Maria Guedes Miguel, Marcia Cristina da Costa Silveira, Ericka Janine Dantas da Actinic cheilitis Squamous cell carcinoma Lip carcinogenesis Oral cancer This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student t test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC (p > 0.05). Immunoexpression of p53 was higher in SCC than in AC (p < 0.001), while p21 expression was more observed in AC when compared to SCC group (p = 0.006). The AC group revealed an inverse correlation between p53 and hMSH2 expression (r = −0.30, p = 0.006). Alterations in p53 and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 and hMSH2 seem to be interrelated in early events of this process. 2017-02-02T11:00:02Z 2017-02-02T11:00:02Z 2016 article LOPES, Maria Luiza Diniz de Souza et al. Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. Archives of Dermatological Research, v. 308, n. 3, p. 165-171, 2016. https://repositorio.ufrn.br/jspui/handle/123456789/21849 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic Actinic cheilitis
Squamous cell carcinoma
Lip carcinogenesis
Oral cancer
spellingShingle Actinic cheilitis
Squamous cell carcinoma
Lip carcinogenesis
Oral cancer
Lopes, Maria Luiza Diniz de Sousa
Oliveira, Denise Hélen Imaculada Pereira de
Sarmento, Dmitry José de Santana
Queiroz, Lelia Maria Guedes
Miguel, Marcia Cristina da Costa
Silveira, Ericka Janine Dantas da
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer
description This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student t test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC (p > 0.05). Immunoexpression of p53 was higher in SCC than in AC (p < 0.001), while p21 expression was more observed in AC when compared to SCC group (p = 0.006). The AC group revealed an inverse correlation between p53 and hMSH2 expression (r = −0.30, p = 0.006). Alterations in p53 and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 and hMSH2 seem to be interrelated in early events of this process.
format article
author Lopes, Maria Luiza Diniz de Sousa
Oliveira, Denise Hélen Imaculada Pereira de
Sarmento, Dmitry José de Santana
Queiroz, Lelia Maria Guedes
Miguel, Marcia Cristina da Costa
Silveira, Ericka Janine Dantas da
author_facet Lopes, Maria Luiza Diniz de Sousa
Oliveira, Denise Hélen Imaculada Pereira de
Sarmento, Dmitry José de Santana
Queiroz, Lelia Maria Guedes
Miguel, Marcia Cristina da Costa
Silveira, Ericka Janine Dantas da
author_sort Lopes, Maria Luiza Diniz de Sousa
title Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer
title_short Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer
title_full Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer
title_fullStr Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer
title_full_unstemmed Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer
title_sort correlation between cell cycle proteins and hmsh2 in actinic cheilitis and lip cancer
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/21849
work_keys_str_mv AT lopesmarialuizadinizdesousa correlationbetweencellcycleproteinsandhmsh2inactiniccheilitisandlipcancer
AT oliveiradenisehelenimaculadapereirade correlationbetweencellcycleproteinsandhmsh2inactiniccheilitisandlipcancer
AT sarmentodmitryjosedesantana correlationbetweencellcycleproteinsandhmsh2inactiniccheilitisandlipcancer
AT queirozleliamariaguedes correlationbetweencellcycleproteinsandhmsh2inactiniccheilitisandlipcancer
AT miguelmarciacristinadacosta correlationbetweencellcycleproteinsandhmsh2inactiniccheilitisandlipcancer
AT silveiraerickajaninedantasda correlationbetweencellcycleproteinsandhmsh2inactiniccheilitisandlipcancer
_version_ 1773959808371654656

Registros relacionados