Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts

OBJECTIVE: Our aim was to assess and compare the immunoexpression of vascular endothelial growth factor (VEGF) in periapical granulomas (PGs), radicular cysts (RCs), and residual radicular cysts (RRCs), relating it to the angiogenic index and the intensity of the inflammatory infiltrate. STUDY DES...

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Principais autores: Nonaka, Cassiano Francisco Weege, Maia, Alexandre Pinto, Nascimento, George João Ferreira do, Freitas, Roseana de Almeida, Souza, Lelia Batista de, Galvão, Hebel Cavalcanti
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Idioma:eng
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Assuntos:
Immunohistochemistry
Endothelial Growth Factors
Odontogenic Cysts
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/21808
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spelling ri-123456789-218082021-12-20T18:36:04Z Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts Nonaka, Cassiano Francisco Weege Maia, Alexandre Pinto Nascimento, George João Ferreira do Freitas, Roseana de Almeida Souza, Lelia Batista de Galvão, Hebel Cavalcanti Immunohistochemistry Endothelial Growth Factors Odontogenic Cysts OBJECTIVE: Our aim was to assess and compare the immunoexpression of vascular endothelial growth factor (VEGF) in periapical granulomas (PGs), radicular cysts (RCs), and residual radicular cysts (RRCs), relating it to the angiogenic index and the intensity of the inflammatory infiltrate. STUDY DESIGN: Twenty PGs, 20 RCs, and 10 RRCs were evaluated by immunohistochemistry using anti-VEGF antibody. Angiogenic index was determined by microvessel count (MVC) using anti-von Willebrand factor antibody. RESULTS: The PGs and RCs showed higher expression of VEGF than the RRCs. Lesions presenting few inflammatory infiltrate revealed the lowest immunoexpression of VEGF (P < .05). Irrespective of the intensity of the inflammatory infiltrate, most of the RCs and RRCs showed moderate to strong epithelial expression of VEGF. Lesions showing dense inflammatory infiltrate presented higher MVC indices (P < .05). VEGF expression and MVC did not reveal a significant correlation (P > .05). CONCLUSIONS: VEGF is present in periapical inflammatory lesions but at a lower level in RRCs. The expression of this proangiogenic factor is closely related to the intensity of the inflammatory infiltrate in these lesions. 2017-01-30T13:56:00Z 2017-01-30T13:56:00Z 2008 article NONAKA, Cassiano Francisco Weege et al. Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts.. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 106, n. 6, p. 896-902, 2008. https://repositorio.ufrn.br/jspui/handle/123456789/21808 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic Immunohistochemistry
Endothelial Growth Factors
Odontogenic Cysts
spellingShingle Immunohistochemistry
Endothelial Growth Factors
Odontogenic Cysts
Nonaka, Cassiano Francisco Weege
Maia, Alexandre Pinto
Nascimento, George João Ferreira do
Freitas, Roseana de Almeida
Souza, Lelia Batista de
Galvão, Hebel Cavalcanti
Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts
description OBJECTIVE: Our aim was to assess and compare the immunoexpression of vascular endothelial growth factor (VEGF) in periapical granulomas (PGs), radicular cysts (RCs), and residual radicular cysts (RRCs), relating it to the angiogenic index and the intensity of the inflammatory infiltrate. STUDY DESIGN: Twenty PGs, 20 RCs, and 10 RRCs were evaluated by immunohistochemistry using anti-VEGF antibody. Angiogenic index was determined by microvessel count (MVC) using anti-von Willebrand factor antibody. RESULTS: The PGs and RCs showed higher expression of VEGF than the RRCs. Lesions presenting few inflammatory infiltrate revealed the lowest immunoexpression of VEGF (P < .05). Irrespective of the intensity of the inflammatory infiltrate, most of the RCs and RRCs showed moderate to strong epithelial expression of VEGF. Lesions showing dense inflammatory infiltrate presented higher MVC indices (P < .05). VEGF expression and MVC did not reveal a significant correlation (P > .05). CONCLUSIONS: VEGF is present in periapical inflammatory lesions but at a lower level in RRCs. The expression of this proangiogenic factor is closely related to the intensity of the inflammatory infiltrate in these lesions.
format article
author Nonaka, Cassiano Francisco Weege
Maia, Alexandre Pinto
Nascimento, George João Ferreira do
Freitas, Roseana de Almeida
Souza, Lelia Batista de
Galvão, Hebel Cavalcanti
author_facet Nonaka, Cassiano Francisco Weege
Maia, Alexandre Pinto
Nascimento, George João Ferreira do
Freitas, Roseana de Almeida
Souza, Lelia Batista de
Galvão, Hebel Cavalcanti
author_sort Nonaka, Cassiano Francisco Weege
title Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts
title_short Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts
title_full Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts
title_fullStr Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts
title_full_unstemmed Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts
title_sort immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/21808
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