Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias

Claudins are transmembrane proteins that play a role in cell proliferation and adhesion and tumourigenesis. This study evaluated the immunoexpression of claudin-1 in the oral epithelial dysplasia (OED) (19 mild, 26 moderate, 3 severe). Diffuse staining predominated in mild (89.4%) and moderate (80.8...

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Principais autores: Carvalho, Marianne de Vasconcelos, Pereira, Joabe dos Santos, Costa, Antonio de Lisboa Lopes, Souza, Lelia Batista de, Freitas, Roseana de Almeida, Miguel, Marcia Cristina da Costa
Formato: article
Idioma:eng
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Assuntos:
Oral epithelial dysplasia
Claudin-1
Tight junctions
Immunohistochemical
Potentially malignant lesion
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/21793
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spelling ri-123456789-217932022-12-15T21:45:11Z Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias Carvalho, Marianne de Vasconcelos Pereira, Joabe dos Santos Costa, Antonio de Lisboa Lopes Souza, Lelia Batista de Freitas, Roseana de Almeida Miguel, Marcia Cristina da Costa Oral epithelial dysplasia Claudin-1 Tight junctions Immunohistochemical Potentially malignant lesion Claudins are transmembrane proteins that play a role in cell proliferation and adhesion and tumourigenesis. This study evaluated the immunoexpression of claudin-1 in the oral epithelial dysplasia (OED) (19 mild, 26 moderate, 3 severe). Diffuse staining predominated in mild (89.4%) and moderate (80.8%) OEDs. Immunoexpression in the middle and upper third was observed in all mild cases, whereas in moderate/severe dysplasias staining was observed in the upper third in 41.4% of cases, in the upper and middle third in 41.4%, and in the upper, middle and lower third in 17.2% (P<0.05). All mild OEDs and 73.1% of moderate cases presented only membrane staining, whereas membrane/cytoplasmic staining was observed in severe cases. Staining intensity was weak in 60% of parakeratinized OEDs and moderate/strong in orthokeratinized OEDs (60.8%) (P>0.05). The differences in the immunoexpression of claudin-1 between different grades of OEDs suggest the involvement of this protein in the progression of dysplasias. 2017-01-30T12:24:59Z 2017-01-30T12:24:59Z 2010 article CARVALHO, Marianne de Vasconcelos et al. Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias. Archives of Oral Biology, v. 55, n. 4, p. 261-267, 2010. https://repositorio.ufrn.br/jspui/handle/123456789/21793 eng Acesso Aberto
institution Repositório Institucional
collection RI - UFRN
language eng
topic Oral epithelial dysplasia
Claudin-1
Tight junctions
Immunohistochemical
Potentially malignant lesion
spellingShingle Oral epithelial dysplasia
Claudin-1
Tight junctions
Immunohistochemical
Potentially malignant lesion
Carvalho, Marianne de Vasconcelos
Pereira, Joabe dos Santos
Costa, Antonio de Lisboa Lopes
Souza, Lelia Batista de
Freitas, Roseana de Almeida
Miguel, Marcia Cristina da Costa
Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias
description Claudins are transmembrane proteins that play a role in cell proliferation and adhesion and tumourigenesis. This study evaluated the immunoexpression of claudin-1 in the oral epithelial dysplasia (OED) (19 mild, 26 moderate, 3 severe). Diffuse staining predominated in mild (89.4%) and moderate (80.8%) OEDs. Immunoexpression in the middle and upper third was observed in all mild cases, whereas in moderate/severe dysplasias staining was observed in the upper third in 41.4% of cases, in the upper and middle third in 41.4%, and in the upper, middle and lower third in 17.2% (P<0.05). All mild OEDs and 73.1% of moderate cases presented only membrane staining, whereas membrane/cytoplasmic staining was observed in severe cases. Staining intensity was weak in 60% of parakeratinized OEDs and moderate/strong in orthokeratinized OEDs (60.8%) (P>0.05). The differences in the immunoexpression of claudin-1 between different grades of OEDs suggest the involvement of this protein in the progression of dysplasias.
format article
author Carvalho, Marianne de Vasconcelos
Pereira, Joabe dos Santos
Costa, Antonio de Lisboa Lopes
Souza, Lelia Batista de
Freitas, Roseana de Almeida
Miguel, Marcia Cristina da Costa
author_facet Carvalho, Marianne de Vasconcelos
Pereira, Joabe dos Santos
Costa, Antonio de Lisboa Lopes
Souza, Lelia Batista de
Freitas, Roseana de Almeida
Miguel, Marcia Cristina da Costa
author_sort Carvalho, Marianne de Vasconcelos
title Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias
title_short Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias
title_full Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias
title_fullStr Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias
title_full_unstemmed Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias
title_sort alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/21793
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