Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip

Objective To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. Study design Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divide...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Barros, Simone Souza Lobão Veras, Henriques, Águida Cristina Gomes, Pereira, Karuza Maria Alves, Medeiros, Ana Miryam Costa de, Galvão, Hebel Cavalcanti, Freitas, Roseana de Almeida
Formato: article
Idioma:eng
Publicado em:
Assuntos:
Matrix metalloproteinases
Immunohistochemistry
Carcinoma
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/21787
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id ri-123456789-21787
record_format dspace
spelling ri-123456789-217872022-12-15T21:46:04Z Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip Barros, Simone Souza Lobão Veras Henriques, Águida Cristina Gomes Pereira, Karuza Maria Alves Medeiros, Ana Miryam Costa de Galvão, Hebel Cavalcanti Freitas, Roseana de Almeida Matrix metalloproteinases Immunohistochemistry Carcinoma Objective To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. Study design Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13). Results Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. Conclusion The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue. 2017-01-30T11:51:48Z 2017-01-30T11:51:48Z 2011 article BARROS, Simone Souza Lobão Veras et al. Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip. Archives of Oral Biology , v. 56, n.8, p. 752-760, 2011. https://repositorio.ufrn.br/jspui/handle/123456789/21787 eng Acesso Aberto
institution Repositório Institucional
collection RI - UFRN
language eng
topic Matrix metalloproteinases
Immunohistochemistry
Carcinoma
spellingShingle Matrix metalloproteinases
Immunohistochemistry
Carcinoma
Barros, Simone Souza Lobão Veras
Henriques, Águida Cristina Gomes
Pereira, Karuza Maria Alves
Medeiros, Ana Miryam Costa de
Galvão, Hebel Cavalcanti
Freitas, Roseana de Almeida
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip
description Objective To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. Study design Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13). Results Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. Conclusion The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue.
format article
author Barros, Simone Souza Lobão Veras
Henriques, Águida Cristina Gomes
Pereira, Karuza Maria Alves
Medeiros, Ana Miryam Costa de
Galvão, Hebel Cavalcanti
Freitas, Roseana de Almeida
author_facet Barros, Simone Souza Lobão Veras
Henriques, Águida Cristina Gomes
Pereira, Karuza Maria Alves
Medeiros, Ana Miryam Costa de
Galvão, Hebel Cavalcanti
Freitas, Roseana de Almeida
author_sort Barros, Simone Souza Lobão Veras
title Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip
title_short Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip
title_full Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip
title_fullStr Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip
title_full_unstemmed Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip
title_sort immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/21787
work_keys_str_mv AT barrossimonesouzalobaoveras immunohistochemicalexpressionofmatrixmetalloproteinasesinsquamouscellcarcinomaofthetongueandlowerlip
AT henriquesaguidacristinagomes immunohistochemicalexpressionofmatrixmetalloproteinasesinsquamouscellcarcinomaofthetongueandlowerlip
AT pereirakaruzamariaalves immunohistochemicalexpressionofmatrixmetalloproteinasesinsquamouscellcarcinomaofthetongueandlowerlip
AT medeirosanamiryamcostade immunohistochemicalexpressionofmatrixmetalloproteinasesinsquamouscellcarcinomaofthetongueandlowerlip
AT galvaohebelcavalcanti immunohistochemicalexpressionofmatrixmetalloproteinasesinsquamouscellcarcinomaofthetongueandlowerlip
AT freitasroseanadealmeida immunohistochemicalexpressionofmatrixmetalloproteinasesinsquamouscellcarcinomaofthetongueandlowerlip
_version_ 1773962348448448512

Registros relacionados