Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs

OBJECTIVE: The aim was to analyze the expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs to determine their roles in cell differentiation processes and invasiveness compared with odontogenesis. STUDY DESIGN: Twenty-one ameloblastoma cases (16 solid and 5 unicystic tumors)...

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Principais autores: Pereira, Karuza Maria Alves, Amaral, Bruna Aguiar do, Santos, Bruna Rafaela Martins dos, Galvão, Hebel Cavalcanti, Freitas, Roseana de Almeida, Souza, Lelia Batista de
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Idioma:eng
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Immunohistochemical
E-cadherin
beta-catenin
ameloblastoma
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/21208
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spelling ri-123456789-212082021-12-21T17:14:08Z Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs Pereira, Karuza Maria Alves Amaral, Bruna Aguiar do Santos, Bruna Rafaela Martins dos Galvão, Hebel Cavalcanti Freitas, Roseana de Almeida Souza, Lelia Batista de Immunohistochemical E-cadherin beta-catenin ameloblastoma OBJECTIVE: The aim was to analyze the expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs to determine their roles in cell differentiation processes and invasiveness compared with odontogenesis. STUDY DESIGN: Twenty-one ameloblastoma cases (16 solid and 5 unicystic tumors) and 5 tooth germs were submitted to the immunohistochemical detection of E-cadherin and beta-catenin. Immunoreactivity was evaluated using descriptive and semiquantitative analysis, investigating the location and intensity of staining. The Fisher exact test was performed, and P values of <.05 were considered to indicate statistical significance. RESULTS: There was no statistically significant difference in the expression of E-cadherin and beta-catenin between solid and unicystic ameloblastomas (P = .59; P = .63; respectively). The same was found when comparing solid and unicystic ameloblastomas with the tooth germs for both E-cadherin (P = .53; P = .44; respectively) and beta-catenin (P = .12; P = .16; respectively). Nuclear staining of beta-catenin was observed in only 4 cases (3 solid and 1 unicystic tumor). CONCLUSION: The results showed no differences in the expression of E-cadherin or beta-catenin between tooth germs and solid and unicystic ameloblastomas. The expression of these molecules seems mainly to be related to the process of cell differentiation. 2016-08-22T16:35:08Z 2016-08-22T16:35:08Z 2010 article PEREIRA, Karuza Maria Alves et al. Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, v. 109, n. 3, p. 425-431, 2010. https://repositorio.ufrn.br/jspui/handle/123456789/21208 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic Immunohistochemical
E-cadherin
beta-catenin
ameloblastoma
spellingShingle Immunohistochemical
E-cadherin
beta-catenin
ameloblastoma
Pereira, Karuza Maria Alves
Amaral, Bruna Aguiar do
Santos, Bruna Rafaela Martins dos
Galvão, Hebel Cavalcanti
Freitas, Roseana de Almeida
Souza, Lelia Batista de
Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
description OBJECTIVE: The aim was to analyze the expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs to determine their roles in cell differentiation processes and invasiveness compared with odontogenesis. STUDY DESIGN: Twenty-one ameloblastoma cases (16 solid and 5 unicystic tumors) and 5 tooth germs were submitted to the immunohistochemical detection of E-cadherin and beta-catenin. Immunoreactivity was evaluated using descriptive and semiquantitative analysis, investigating the location and intensity of staining. The Fisher exact test was performed, and P values of <.05 were considered to indicate statistical significance. RESULTS: There was no statistically significant difference in the expression of E-cadherin and beta-catenin between solid and unicystic ameloblastomas (P = .59; P = .63; respectively). The same was found when comparing solid and unicystic ameloblastomas with the tooth germs for both E-cadherin (P = .53; P = .44; respectively) and beta-catenin (P = .12; P = .16; respectively). Nuclear staining of beta-catenin was observed in only 4 cases (3 solid and 1 unicystic tumor). CONCLUSION: The results showed no differences in the expression of E-cadherin or beta-catenin between tooth germs and solid and unicystic ameloblastomas. The expression of these molecules seems mainly to be related to the process of cell differentiation.
format article
author Pereira, Karuza Maria Alves
Amaral, Bruna Aguiar do
Santos, Bruna Rafaela Martins dos
Galvão, Hebel Cavalcanti
Freitas, Roseana de Almeida
Souza, Lelia Batista de
author_facet Pereira, Karuza Maria Alves
Amaral, Bruna Aguiar do
Santos, Bruna Rafaela Martins dos
Galvão, Hebel Cavalcanti
Freitas, Roseana de Almeida
Souza, Lelia Batista de
author_sort Pereira, Karuza Maria Alves
title Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
title_short Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
title_full Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
title_fullStr Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
title_full_unstemmed Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
title_sort immunohistochemical expression of e-cadherin and beta-catenin in ameloblastomas and tooth germs
publishDate 2016
url https://repositorio.ufrn.br/jspui/handle/123456789/21208
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AT galvaohebelcavalcanti immunohistochemicalexpressionofecadherinandbetacatenininameloblastomasandtoothgerms
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