Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study

Mostrar outras versões (1)

Objective to evaluate the association between XPD and XRCC3 polymorphisms and oral squamous cell carcinoma (OSCC). Design the sample consisted of 54 cases of OSCC and 40 cases of inflammatory fibrous hyperplasia (IFH). Genotypes were determined by the polymerase chain reaction-restriction f...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Pereira, Joabe dos Santos, Fontes, Fabrícia Lima, Medeiros, Sílvia Regina Batistuzzo de, Freitas, Roseana de Almeida, Souza, Lelia Batista de, Miguel, Marcia Cristina da Costa
Formato: article
Idioma:eng
Publicado em:
Assuntos:
DNA repair
Genetic polymorphisms
Oral cancer
Restriction fragment length polymorphisms
Squamous cell carcinoma
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/21200
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id ri-123456789-21200
record_format dspace
spelling ri-123456789-212002021-12-21T17:25:24Z Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study Pereira, Joabe dos Santos Fontes, Fabrícia Lima Medeiros, Sílvia Regina Batistuzzo de Freitas, Roseana de Almeida Souza, Lelia Batista de Miguel, Marcia Cristina da Costa DNA repair Genetic polymorphisms Oral cancer Restriction fragment length polymorphisms Squamous cell carcinoma Objective to evaluate the association between XPD and XRCC3 polymorphisms and oral squamous cell carcinoma (OSCC). Design the sample consisted of 54 cases of OSCC and 40 cases of inflammatory fibrous hyperplasia (IFH). Genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results XPD-Lys/Gln was more common in IFH (n = 28; 70%) than in OSCC (n = 24; 44.4%) (OR: 0.3; p < 0.05). XPD-Gln was more frequent in high-grade lesions (0.48) than in low-grade lesions (0.21) (OR: 3.4; p < 0.05). The Gln/Gln genotype was associated with III and IV clinical stages (OR: 0.07; p < 0.05). XRCC3-Met was more frequent in OSCC (0.49) than in IFH (0.35) (OR: 2.6; p < 0.05). The Met/Met genotype was associated with the presence of metastases (OR: 8.1; p < 0.05) and with III and IV clinical stages (OR: 0.07; p < 0.05). Conclusions in this sample, the frequency of XPD-Gln in IFH suggests that this variant may protect against OSCC. The presence of the XRCC3-Met allele seems to contribute to the development of OSCC, metastases and more advanced stages in these lesions. 2016-08-22T12:42:58Z 2016-08-22T12:42:58Z 2016 article PEREIRA, Joabe dos Santos et al. Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study. Archives of Oral Biology , v. 64, p. 19-23, 2016. https://repositorio.ufrn.br/jspui/handle/123456789/21200 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic DNA repair
Genetic polymorphisms
Oral cancer
Restriction fragment length polymorphisms
Squamous cell carcinoma
spellingShingle DNA repair
Genetic polymorphisms
Oral cancer
Restriction fragment length polymorphisms
Squamous cell carcinoma
Pereira, Joabe dos Santos
Fontes, Fabrícia Lima
Medeiros, Sílvia Regina Batistuzzo de
Freitas, Roseana de Almeida
Souza, Lelia Batista de
Miguel, Marcia Cristina da Costa
Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study
description Objective to evaluate the association between XPD and XRCC3 polymorphisms and oral squamous cell carcinoma (OSCC). Design the sample consisted of 54 cases of OSCC and 40 cases of inflammatory fibrous hyperplasia (IFH). Genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results XPD-Lys/Gln was more common in IFH (n = 28; 70%) than in OSCC (n = 24; 44.4%) (OR: 0.3; p < 0.05). XPD-Gln was more frequent in high-grade lesions (0.48) than in low-grade lesions (0.21) (OR: 3.4; p < 0.05). The Gln/Gln genotype was associated with III and IV clinical stages (OR: 0.07; p < 0.05). XRCC3-Met was more frequent in OSCC (0.49) than in IFH (0.35) (OR: 2.6; p < 0.05). The Met/Met genotype was associated with the presence of metastases (OR: 8.1; p < 0.05) and with III and IV clinical stages (OR: 0.07; p < 0.05). Conclusions in this sample, the frequency of XPD-Gln in IFH suggests that this variant may protect against OSCC. The presence of the XRCC3-Met allele seems to contribute to the development of OSCC, metastases and more advanced stages in these lesions.
format article
author Pereira, Joabe dos Santos
Fontes, Fabrícia Lima
Medeiros, Sílvia Regina Batistuzzo de
Freitas, Roseana de Almeida
Souza, Lelia Batista de
Miguel, Marcia Cristina da Costa
author_facet Pereira, Joabe dos Santos
Fontes, Fabrícia Lima
Medeiros, Sílvia Regina Batistuzzo de
Freitas, Roseana de Almeida
Souza, Lelia Batista de
Miguel, Marcia Cristina da Costa
author_sort Pereira, Joabe dos Santos
title Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study
title_short Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study
title_full Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study
title_fullStr Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study
title_full_unstemmed Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study
title_sort association of the xpd and xrcc3 gene polymorphisms with oral squamous cell carcinoma in a northeastern brazilian population: a pilot study
publishDate 2016
url https://repositorio.ufrn.br/jspui/handle/123456789/21200
work_keys_str_mv AT pereirajoabedossantos associationofthexpdandxrcc3genepolymorphismswithoralsquamouscellcarcinomainanortheasternbrazilianpopulationapilotstudy
AT fontesfabricialima associationofthexpdandxrcc3genepolymorphismswithoralsquamouscellcarcinomainanortheasternbrazilianpopulationapilotstudy
AT medeirossilviareginabatistuzzode associationofthexpdandxrcc3genepolymorphismswithoralsquamouscellcarcinomainanortheasternbrazilianpopulationapilotstudy
AT freitasroseanadealmeida associationofthexpdandxrcc3genepolymorphismswithoralsquamouscellcarcinomainanortheasternbrazilianpopulationapilotstudy
AT souzaleliabatistade associationofthexpdandxrcc3genepolymorphismswithoralsquamouscellcarcinomainanortheasternbrazilianpopulationapilotstudy
AT miguelmarciacristinadacosta associationofthexpdandxrcc3genepolymorphismswithoralsquamouscellcarcinomainanortheasternbrazilianpopulationapilotstudy
_version_ 1745766938700677120

Registros relacionados