Efeitos da terapia laser de baixa intensidade associada ao exercício aeróbio no reparo de tenotomia do tendão de aquiles de ratos diabéticos
Diabetes Mellitus (DM ) is a complex disease that requires continuous medical care for the reduction of risk factors in addition to glycemic control. The typical hyperglycemia of this disease produces glycosylation of proteins and so the consequence is the accumulation of glycosylation final prod...
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Formato: | Dissertação |
Idioma: | por |
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Universidade Federal do Rio Grande do Norte
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Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/21101 |
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Resumo: | Diabetes Mellitus (DM ) is a complex disease that requires continuous medical
care for the reduction of risk factors in addition to glycemic control. The typical
hyperglycemia of this disease produces glycosylation of proteins and so the
consequence is the accumulation of glycosylation final products in various human
tissues, among them, the tendon. The aerobic exercise (AE) and the low level
laser therapy (LLLT) have been used to treat tendinopathies in individuals with or
without DM. Objective: The aim of this study was to watch the effect of the LLLT
and the AE, in association, in partial tenotomy of the tissue repair of the Achilles
tendon (AT) of diabetic rats. Methods: 91 animals were utilized and divided in to
the following groups: control group (GC), injured control group (GCL), diabetic
group (GD), diabetic group LLLT (GD – TLBI), diabetic group trained (GD - EX)
and diabetic group trained laser (GD-EX+TLBI). The animals were submitted to
intervention with AE, using a protocol with a progressive increase of time (12 to
60 min) and speed of (4 to 9 m/min), and the LLLT (660 nm laser, 10mW, 4 J/cm²,
single point for 16 seconds, three times for week). It was analyzed morphological,
biomechanical and molecular characteristics. For data showing normal
distribution was used one-way ANOVA test and post hoc Tukey and data without
normal distribution was used Mann Whitney test and post hoc Dunn's. It was
accepted p <0.05 for statistical significance Results: The biomechanical tests
indicated major improvement in the GC and GD-EX+TLBI groups when
compared with the diabetic groups in the following variables: maximum load,
strain, absorbed energy, stress, cross section area, elastic modulus and energy
density (p<0.05). The analysis through molecular biology indicated that the
association of aerobic exercise and LLLT generated an increase of the collagen
I gene expression and modulated the expression of the MMP2 and MMP9
(p<0.05). No observed any major improvement in the morphological variable
studied. Conclusion: the LLLT associated with aerobic exercise promotes and
increase of the mechanical properties, in the control of collagen I gene expression
and of the MMP2 and MMP9 of the diabetic rats. |
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