Avaliação da suplementação materna com palmitato de retinila sobre os níveis de retinol e alfa-tocoferol no leite humano
Vitamins A and E are lipophilic nutrients that act in many important biological processes, such as immunity, reproduction, growth, and development. These vitamins are essential during the initial phase of life and should be properly transferred from mother to child during pregnancy and lactation....
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| Formato: | Dissertação |
| Idioma: | por |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/20328 |
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| Resumo: | Vitamins A and E are lipophilic nutrients that act in many important biological
processes, such as immunity, reproduction, growth, and development. These
vitamins are essential during the initial phase of life and should be properly
transferred from mother to child during pregnancy and lactation. Maternal
supplementation with vitamin A is one of the strategies for controlling its deficiency in
the mother-child dyad, but studies with animals showed that supplementation with
high doses of vitamin A reduces the levels of alpha-tocopherol (vitamin E) in the
mother’s serum and milk. Hence, the objective of this study was to assess the
influence of maternal supplementation with vitamin A on the concentration of retinol
and alpha-tocopherol in colostrum and mature milk. Healthy puerperal women with
term deliveries were randomly distributed into a control group (n=44) and a
supplemented group (n=44). Blood and colostrum samples were collected
immediately after delivery, and mature blood samples were collected 30 days later.
The supplemented group received 200,000 IU of retinyl palmitate immediately after
the first colostrum collection. The retinol and alpha-tocopherol levels in the biological
samples were determined by high-performance liquid chromatography (HPLC).
Serum vitamin A levels below 20 µg/dL and serum vitamin E levels below 516 µg/dL
indicated deficiency. The retinol and alpha-tocopherol levels in the maternal serum
were considered adequate at 46.4 ± 15.9 µg/ dL and 1,023.6 ± 380.4 µg/ dL,
respectively. The colostrum retinol levels of the supplemented group increased
significantly 24 hours after the intervention (p<0.001). However, the retinol levels in
the mature milk of both groups did not differ (p>0.05). Moreover, after maternal
supplementation with vitamin A, colostrum alpha-tocopherol level decreased by
16.4%, a significant reduction (p<0.05). However, vitamin A supplementation did not
affect the alpha-tocopherol level of mature milk (p>0.05). In conclusion, maternal
supplementation with high doses of vitamin A increased the colostrum level of this
nutrient but reduced the bioavailability of alpha-tocopherol, which may harm the
newborn’s health since newborns have limited vitamin E reserves. |
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