Live Imaging of Adult Neural Stem Cells in Rodents
The generation of cells of the neural lineage within the brain is not restricted to early development. New neurons, oligodendrocytes, and astrocytes are produced in the adult brain throughout the entire murine life. However, despite the extensive research performed in the field of adult neurogene...
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Principais autores: | , |
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Formato: | article |
Idioma: | eng |
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Universidade Federal do Rio Grande do Norte
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Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/19997 |
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Resumo: | The generation of cells of the neural lineage within the brain is not restricted to early
development. New neurons, oligodendrocytes, and astrocytes are produced in the
adult brain throughout the entire murine life. However, despite the extensive research
performed in the field of adult neurogenesis during the past years, fundamental questions
regarding the cell biology of adult neural stem cells (aNSCs) remain to be uncovered. For
instance, it is crucial to elucidate whether a single aNSC is capable of differentiating
into all three different macroglial cell types in vivo or these distinct progenies constitute
entirely separate lineages. Similarly, the cell cycle length, the time and mode of division
(symmetric vs. asymmetric) that these cells undergo within their lineage progression are
interesting questions under current investigation. In this sense, live imaging constitutes
a valuable ally in the search of reliable answers to the previous questions. In spite of the
current limitations of technology new approaches are being developed and outstanding
amount of knowledge is being piled up providing interesting insights in the behavior of
aNSCs. Here, we will review the state of the art of live imaging as well as the alternative
models that currently offer new answers to critical questions. |
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