Alfa-tocoferol previne os déficits cognitivos, motores e neuronais em um modelo de parkinson progressivo em ratos
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects 1-2% of world population, with a higher prevalence among men. The main symptoms are of motor nature, and include bradikynesia, rigidity, postural instability and tremor. In addition, non-motor symptoms may occur, su...
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| Formato: | doctoralThesis |
| Idioma: | por |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/19766 |
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| Resumo: | Parkinson’s disease (PD) is a progressive neurodegenerative disorder that
affects 1-2% of world population, with a higher prevalence among men. The
main symptoms are of motor nature, and include bradikynesia, rigidity, postural
instability and tremor. In addition, non-motor symptoms may occur, such as
sleep disturbances, anxiety, depression, and cognitive deficits. The motor
alterations are a consequence of the irreversible loss of dopaminergic neurons
mainly in the substantia nigra pars compacta. The most effective current
treatment for PD is L-DOPA administration. However, this drug, despite
amegliorating symptoms, does not interfere with the neurodegeneration, and
thus has limitations at long term. Thus, alternative treaments that could act by
neuroprotective mechanisms have been considered, such as antioxidant
agents. The mechanisms related to the symptoms and progressive nature of PD
can be studied in animal models. In this sense, the aim of the present study was
to investigate the effects of the antioxidant α-tocopherol on the motor, cognitive
and neuronal deficits induced by repeated treatment with reserpine (a
progressive pharmacological model of parkinsonism). Rats submitted to the
reserpine protocol were concomitantly treated with α-tocopherol. The results
showed that the repeated treatment with reserpine, as expected, induced
progressive motor and cognitive decrements, as well as dimished tyrosine
hydroxylase immunostaining in the substantia nigra pars compacta and
striatum. These deficits were not present in the animals that were co-treated
with α-tocoferol, suggesting a possible neuroprotective effect induced by this
antioxidant agent. In conclusion, α-tocoferol was able to prevent the alterations
caused by repeated reserpine administration. In addition, our study suggest that
low-dose reserpine-induced progressive motor and cognitive deficits can be
useful in the study of possible neuroprotective strategies for PD. |
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