Parâmetros bioquímicos e níveis de IgE total e específicas para aeroalérgenos em mulheres obesas com síndrome dos ovários policísticos
Introduction: Polycystic ovary syndrome (PCOS) whose classic features (menstrual irregularity of oligo/ amenorrhea type, chronic anovulation, infertility and hyperandrogenism clinical and/ or biochemical), is associated with aspects of metabolic syndrome (MS), as obesity and insulin resistance. T...
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Formato: | Dissertação |
Idioma: | por |
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Universidade Federal do Rio Grande do Norte
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Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/19495 |
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Resumo: | Introduction: Polycystic ovary syndrome (PCOS) whose classic features (menstrual irregularity of
oligo/ amenorrhea type, chronic anovulation, infertility and hyperandrogenism clinical and/ or
biochemical), is associated with aspects of metabolic syndrome (MS), as obesity and insulin
resistance. The level of obesity determines different levels of inflammation, increasing cytokines
participants of metabolic and endocrine functions, beyond modulate the immune response. Metabolic
changes, added to the imbalance of sex hormones underlying irregular menstruation observed in
(PCOS) can trigger allergic processes and elevation of total and specific IgE antibodies indicate that
a sensitization process was started. Objective: To evaluate the influence of PCOS on biochemical
parameters and levels of total and specific IgE to aeroallergens in obese women. Methods: After
approval by the Committee of Ethics in Research, were recruited 80 volunteers with BMI ≥ 30 kg/m2
and age between 18 and 45 years. Among these, 40 with PCOS according to the Rotterdam criteria
and 40 women without PCOS (control group). All participants were analysed with regard to
anthropometric, clinical, gynecological parameters, interviewed using a questionnaire, and
underwent blood sampling for realization of laboratory tests of clinical biochemistry: Total
cholesterol, LDL-cholesterol, HDL- cholesterol, Triglycerides, Fasting glucose, Urea, Creatinine,
Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and immunological: total and
specific IgE to Dermatophagoides pteronyssinus, Blomia tropicalis, Dermatophagoides farinae and
Dermatophagoides microceras.Statistical analysis was performed using SPSS 15.0 software through
the chi-square tests, Fisher, Student t test and binary logistic regression, with significance level (p
<0.05). Results: It was observed in the group of obese women with PCOS that 29 (72.5%) had
menstrual cycle variable and 27 (67.5%) had difficulty getting pregnant. According to waist-hip
ratio, higher average was also observed in obese PCOS (0.87). Blood level of HDL (36.9 mg/dL) and
ALT (29.3 U/L) were above normal levels in obese women with PCOS, with statistically significant
relationship. In the analysis of total and specific IgE to D. pteronyssinus high results were also
prevalent in obese PCOS, with blood level (365,22 IU/mL) and (6.83 kU/L), respectively, also
statistically significant. Conclusions: Observed predominance of cases with high levels of total IgE
in the group of obese women with PCOS, 28 (70%) of the participants, whose mean blood
concentration of the group was 365.22 IU/mL. In the analysis of Specific IgE between the groups,
the allergen Dermatophagoides pteronyssinus showed greater dispersion and average the results of
sensitization in the group of obese PCOS, whose mean blood concentration was 6.83 kU/l.
Keywords: Obesity, Allergens and Polycystic Ovary Syndrome |
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