Desenvolvimento de emulsões o/a contendo extrato glicólico de açai e avaliação da atividade fotoprotetora
Sunscreen use is the most common photoprotection alternative used by the population, and so these products should offer improved protection with broad - spectrum, UVA and UVB protection . Vegetal substances have recently been considered as resources f...
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Formato: | Dissertação |
Idioma: | por |
Publicado em: |
Universidade Federal do Rio Grande do Norte
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Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/19364 |
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Resumo: | Sunscreen use is the most common photoprotection alternative used by the
population, and so these products should offer improved protection with
broad
-
spectrum, UVA and UVB protection
. Vegetal substances have recently been
considered as resources for sunscreen formulations due to their UV spectrum
absorption and antioxidant properties. The
Euterpe oleracea
Mart., popularly known
as açai,
in its che
mical composition
contain polyphenols
compounds, such
as
anthocyanins
and
flavonoids
,
to
which antioxidant properties have been attributed
.
The aim of this work was to develop O/W sunscreens emulsions con
taining açai
glycolic extract (
AGE) and to evaluate
both their physical stability
, safety
and
photoprotective efficacy.
The safety of the extract was evaluated by
in vitro
phototoxicity and cytotoxicity tests.
Emulsions containing AGE and sunscreens were
formulated using different types and concentrations o
f polymeric surfactant
(Acrylates/C 10
-
30 Alkyl Acrylate Crosspolymer and Sodium Polyacrylate). The
influence of two rheology modifiers (Polyacrylamide (and) C13
-
14/Isoparaffin (and)
Laureth
-
7 and Carbomer) on the stability was also investigated. Physical
stability was
evaluated by preliminary and accelerated studies. The macroscopic analyses, pH
value
and electrical conductivity
determinations and rheological behavior were
evaluated at different time intervals
.
The
in vivo
Sun Protect Factor (
SPF
)
was
determined according to the International Sun Protection Factor Test Method
–
2006
and UVA Protection Factor (FPUVA), wavelength critical and reason SPF/FPUVA
were performed according to the method Colipa 2011. The extract did not present
cytotoxic
ity
and phototoxic
ity
. The stable emulsion containing 5% glycolic extract of
açai and 1.0% of sodium poliyacrylate
showed pseudoplastic and thixotropic
behavior
.
The sunscreen emulsion containing açai glycolic extract showed a SPF
25.3 and
PF
-
UVA = 14.97. Whe
n açai glycolic extract was added in the emulsion
sunscreen, no significant increase in the
in vivo
SPF and FPUVA values were
observed. This emulsion showed 1.69 of the SPF/PF
-
UVA ratio and a critical
wavelength value of 378
nm,
so
may therefore be conside
red a sunscreen with UVA
and UVB protection. |
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