Medial prefrontal cortex dopamine controls the persistent storage of aversive memories
Medial prefrontal cortex (mPFC) is essential for initial memory processing and expression but its involvement in persistent memory storage has seldom been studied. Using the hippocampus dependent inhibitory avoidance learning task and the hippocampus-independent conditioned taste aversion paradig...
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ri-123456789-190752021-07-09T21:04:49Z Medial prefrontal cortex dopamine controls the persistent storage of aversive memories Gonzalez, María C. Kramar, Cecilia P. Tomaiuolo, Micol Katche, Cynthia Weisstaub, Noelia Cammarota, Martín Pablo Medina, Jorge H. inhibitory avoidance conditioned taste aversion D1/D5 receptor VTA system consolidation Medial prefrontal cortex (mPFC) is essential for initial memory processing and expression but its involvement in persistent memory storage has seldom been studied. Using the hippocampus dependent inhibitory avoidance learning task and the hippocampus-independent conditioned taste aversion paradigm together with specific dopamine receptor agonists and antagonists we found that persistence but not formation of long-term aversive memories requires dopamine D1/D5 receptors activation in mPFC immediately after training and, depending on the task, between 6 and 12 h later. Our results indicate that besides its well-known participation in retrieval and early consolidation, mPFC also modulates the endurance of long-lasting aversive memories regardless of whether formation of the aversive mnemonic trace requires the participation of the hippocampus. Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT, Argentina) to Jorge H. Medina; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil) and Fundação de Amparo à Pesquisa do Estado do Rio Grande do Norte (FAPERN, Brazil) to Martín Cammarota; and International Brain Research Organization (IBRO) to Jorge H. Medina and Martín Cammarota. 2015-06-10T19:41:19Z 2015-06-10T19:41:19Z 2014-11-26 article Gonzalez MC, Kramar CP, Tomaiuolo M, Katche C, Weisstaub N, Cammarota M and Medina JH (2014) Medial prefrontal cortex dopamine controls the persistent storage of aversive memories. Front. Behav. Neurosci. 8:408. doi: 10.3389/ fnbeh.2014.00408 1662-5153 https://repositorio.ufrn.br/jspui/handle/123456789/19075 en_US application/pdf |
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inhibitory avoidance conditioned taste aversion D1/D5 receptor VTA system consolidation |
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inhibitory avoidance conditioned taste aversion D1/D5 receptor VTA system consolidation Gonzalez, María C. Kramar, Cecilia P. Tomaiuolo, Micol Katche, Cynthia Weisstaub, Noelia Cammarota, Martín Pablo Medina, Jorge H. Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
description |
Medial prefrontal cortex (mPFC) is essential for initial memory processing and
expression but its involvement in persistent memory storage has seldom been
studied. Using the hippocampus dependent inhibitory avoidance learning task and the
hippocampus-independent conditioned taste aversion paradigm together with specific
dopamine receptor agonists and antagonists we found that persistence but not formation
of long-term aversive memories requires dopamine D1/D5 receptors activation in mPFC
immediately after training and, depending on the task, between 6 and 12 h later.
Our results indicate that besides its well-known participation in retrieval and early
consolidation, mPFC also modulates the endurance of long-lasting aversive memories
regardless of whether formation of the aversive mnemonic trace requires the participation
of the hippocampus. |
format |
article |
author |
Gonzalez, María C. Kramar, Cecilia P. Tomaiuolo, Micol Katche, Cynthia Weisstaub, Noelia Cammarota, Martín Pablo Medina, Jorge H. |
author_facet |
Gonzalez, María C. Kramar, Cecilia P. Tomaiuolo, Micol Katche, Cynthia Weisstaub, Noelia Cammarota, Martín Pablo Medina, Jorge H. |
author_sort |
Gonzalez, María C. |
title |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
title_short |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
title_full |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
title_fullStr |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
title_full_unstemmed |
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
title_sort |
medial prefrontal cortex dopamine controls the persistent storage of aversive memories |
publishDate |
2015 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/19075 |
work_keys_str_mv |
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