Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson’s Disease: New Perspectives to a Long-Standing Model

he administration of reserpine to rodents was one of the first models used to investigate the pathophysiology and screening for potential treatments of Parkinson’s disease (PD). The reserpine model was critical to the understanding of the role of monoamine system in the regulation of motor and af...

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Principais autores: Leão, Anderson H.F.F., Sarmento-Silva, Aldair J., Santos, José R., Ribeiro, Alessandra M., Silva, Regina H.
Formato: article
Idioma:en_US
Publicado em: Wiley
Assuntos:
animal model
dopamine
Parkinson’s disease
reserpine
rodent
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/19023
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spelling ri-123456789-190232022-10-17T21:48:01Z Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson’s Disease: New Perspectives to a Long-Standing Model Leão, Anderson H.F.F. Sarmento-Silva, Aldair J. Santos, José R. Ribeiro, Alessandra M. Silva, Regina H. animal model dopamine Parkinson’s disease reserpine rodent he administration of reserpine to rodents was one of the first models used to investigate the pathophysiology and screening for potential treatments of Parkinson’s disease (PD). The reserpine model was critical to the understanding of the role of monoamine system in the regulation of motor and affective disorders, as well as the efficacy of current PD treatments, such as L-DOPA and dopamine agonists. Nevertheless, with the introduction of toxin-induced and genetic models of PD, reserpine became underused. The main rationale to this drawback was the supposed absence of reserpine construct validity with PD. Here, we highlight classical and recent experimental findings that support the face, pharmacological, and construct validity of reserpine PD model and reason against the current rationale for its underuse. We also aim to shed a new perspective upon the model by discussing the main challenges and potentials for the reserpine model of PD. 2015-04-30T19:32:45Z 2015-04-30T19:32:45Z 2015-03-02 article LEÃO, Anderson H.F.F. et al. Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson’s Disease: New Perspectives to a Long-Standing Model. Brain Pathology. doi:10.1111/bpa.12253 1015-6305 https://repositorio.ufrn.br/jspui/handle/123456789/19023 en_US Wiley
institution Repositório Institucional
collection RI - UFRN
language en_US
topic animal model
dopamine
Parkinson’s disease
reserpine
rodent
spellingShingle animal model
dopamine
Parkinson’s disease
reserpine
rodent
Leão, Anderson H.F.F.
Sarmento-Silva, Aldair J.
Santos, José R.
Ribeiro, Alessandra M.
Silva, Regina H.
Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson’s Disease: New Perspectives to a Long-Standing Model
description he administration of reserpine to rodents was one of the first models used to investigate the pathophysiology and screening for potential treatments of Parkinson’s disease (PD). The reserpine model was critical to the understanding of the role of monoamine system in the regulation of motor and affective disorders, as well as the efficacy of current PD treatments, such as L-DOPA and dopamine agonists. Nevertheless, with the introduction of toxin-induced and genetic models of PD, reserpine became underused. The main rationale to this drawback was the supposed absence of reserpine construct validity with PD. Here, we highlight classical and recent experimental findings that support the face, pharmacological, and construct validity of reserpine PD model and reason against the current rationale for its underuse. We also aim to shed a new perspective upon the model by discussing the main challenges and potentials for the reserpine model of PD.
format article
author Leão, Anderson H.F.F.
Sarmento-Silva, Aldair J.
Santos, José R.
Ribeiro, Alessandra M.
Silva, Regina H.
author_facet Leão, Anderson H.F.F.
Sarmento-Silva, Aldair J.
Santos, José R.
Ribeiro, Alessandra M.
Silva, Regina H.
author_sort Leão, Anderson H.F.F.
title Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson’s Disease: New Perspectives to a Long-Standing Model
title_short Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson’s Disease: New Perspectives to a Long-Standing Model
title_full Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson’s Disease: New Perspectives to a Long-Standing Model
title_fullStr Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson’s Disease: New Perspectives to a Long-Standing Model
title_full_unstemmed Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson’s Disease: New Perspectives to a Long-Standing Model
title_sort molecular, neurochemical, and behavioral hallmarks of reserpine as a model for parkinson’s disease: new perspectives to a long-standing model
publisher Wiley
publishDate 2015
url https://repositorio.ufrn.br/jspui/handle/123456789/19023
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