Specification of excitatory neurons in the developing cerebral cortex: progenitor diversity and environmental influences
The mature cerebral cortex harbors a heterogeneous population of glutamatergic neurons, organized into a highly intricate histological architecture. Classically, this mixed population of neurons was thought to be generated sequentially from a seemingly homogenous group of progenitors under the in...
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| Principais autores: | , |
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| Formato: | article |
| Idioma: | en_US |
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/18984 |
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| Resumo: | The mature cerebral cortex harbors a heterogeneous population of glutamatergic neurons,
organized into a highly intricate histological architecture. Classically, this mixed population
of neurons was thought to be generated sequentially from a seemingly homogenous
group of progenitors under the influence of external cues. This view, however, has been
challenged in the last decade by evidences pointing to the existence of fate-restricted
neuronal progenitors in the developing neocortex. Here, we review classical studies
using cell transplantation, retroviral labeling and cell culture, as well as new data from
genetic fate-mapping analysis, to discuss the lineage relationships between neocortical
progenitors and subclasses of excitatory neurons. We also propose a temporal model to
conciliate the existence of fate-restricted progenitors alongside multipotent progenitors in
the neocortex. Finally, we discuss evidences for a critical period of plasticity among post
mitotic excitatory cortical neurons when environmental influences could change neuronal
cell fate. |
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