Astrocyte heterogeneity in the brain: from development to disease
In the last decades, astrocytes have risen from passive supporters of neuronal activity to central players in brain function and cognition. Likewise, the heterogeneity of astrocytes starts to become recognized in contrast to the homogeneous population previously predicted. In this review, we focu...
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| Principais autores: | , , , |
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| Formato: | article |
| Idioma: | en_US |
| Publicado em: |
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/18983 |
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| Resumo: | In the last decades, astrocytes have risen from passive supporters of neuronal activity to
central players in brain function and cognition. Likewise, the heterogeneity of astrocytes
starts to become recognized in contrast to the homogeneous population previously
predicted. In this review, we focused on astrocyte heterogeneity in terms of their
morphological, protein expression and functional aspects, and debate in a historical
perspective the diversity encountered in glial progenitors and how they may reflect
mature astrocyte heterogeneity. We discussed data that show that different progenitors
may have unsuspected roles in developmental processes. We have approached the
functions of astrocyte subpopulations on the onset of psychiatric and neurological
diseases. |
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