Aplicação das técnicas eletroanalíticas (voltametria cíclica e de pulso diferencial) usando o eletrodo de diamante dopado com boro para o estudo da isoniazida, etambutol, rifampicina e pirazinamida
In this work a study was done using electrochemical cyclic voltammetry and differential pulse voltammetry for isoniazida (INH), ethambutol (EMB), rifampicina (RIF) and pyrazinamide (PZA) using the electrode boron-doped diamond (BDD) as working electrode. It also verified the applicability of the tec...
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| Formato: | Dissertação |
| Idioma: | por |
| Publicado em: |
Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/17761 |
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| Resumo: | In this work a study was done using electrochemical cyclic voltammetry and
differential pulse voltammetry for isoniazida (INH), ethambutol (EMB), rifampicina
(RIF) and pyrazinamide (PZA) using the electrode boron-doped diamond (BDD) as
working electrode. It also verified the applicability of the technique of differential pulse
voltammetry in the quantification of the active compounds used in the treatment of
tuberculosis, subsequently applying in samples of pharmaceutical formulation.
Among the four active compounds studied, isoniazid showed the best results for the
detection and quantification using differential pulse voltammetry. At pH 4 and pH 8,
for the calibration curves to INH showed good linearity, with quantification limits of
6.15 mmol L-1 (0,844 ppm) and 4.08 mmol L-1 (0.560 ppm) for the respective pH. The
proposed method can be used to determine drug isoniazid, for recovery values were
obtained in approximately 100% |
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