Análise imunoistoquímica da distribuição de Serotonina, transportador de serotonina e receptores de serotonina no hipotálamo do sagui (callithrix jacchus)
The hypothalamus is a diencephalic portion located around the third ventricle below the hypothalamic sulcus, limited by the optic chiasm, and by the mammillary bodies, acting as a center that integrates behavioral and homeostatic functions. Serotonin is a neurotransmitter produced in limited sites i...
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Formato: | Dissertação |
Idioma: | por |
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Universidade Federal do Rio Grande do Norte
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Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/17320 |
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Resumo: | The hypothalamus is a diencephalic portion located around the third ventricle below the
hypothalamic sulcus, limited by the optic chiasm, and by the mammillary bodies, acting as
a center that integrates behavioral and homeostatic functions. Serotonin is a
neurotransmitter produced in limited sites in the midbrain and brain stem, but is distributed
throughout the central nervous system and has many functions, acting through specific
receptors that are also distributed throughout the nervous system. Using
immunohistochemical techniques, the aim of this study was to delineate the hypothalamic
nuclei of the marmoset (Callithrix jacchus) and study the distribution of serotonin
transporter and serotonin receptors in the hypothalamus of this species. We used the Nissl
method to determine the cytoarchitecture of the hypothalamic nuclei, and
immunohistochemistry to reveal the presence of NeuN as a method to determine the
contours of the hypothalamic nuclei. As a result, we found serotonin containing fibers and
terminals throughout the rostrocaudal extent of the hypothalamus, more concentrated in
some nuclei, and even absent in some. Like serotonin, serotonin transporter was observed
between pre-optic area and tuberal region of the hypothalamus, in densities and
distribution similar to serotonin. The 5-HT1A and 5-HT1B receptors were found with minor
differences among itselves regarding the disposition and intensity of staining. |
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