Expressão Imuno-histoquímica das proteínas GLUT-1 e HIF-1α em lesões vasculares de mucosa oral
The correct histological diagnosis of vascular lesions in the oral mucosa is critical, especially in defining the treatment and prognosis, as some vascular lesions show spontaneous involution and others do not show such behavior. This study analyzed the expression immunohistochemistry of human gl...
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Formato: | Dissertação |
Idioma: | por |
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Universidade Federal do Rio Grande do Norte
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Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/17117 |
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Resumo: | The correct histological diagnosis of vascular lesions in the oral mucosa is
critical, especially in defining the treatment and prognosis, as some vascular lesions
show spontaneous involution and others do not show such behavior. This study
analyzed the expression immunohistochemistry of human glucose transporter protein
(GLUT-1), in oral benign vascular tumors and to reclassify such lesions according to
with his immunoexpression. In addition, we evaluated the immunohistochemical
expression of hypoxia-inducible factor 1 alpha (HIF-1α), the main transcription factor
involved in cellular adaptation to hypoxia. We analyzed 60 cases of benign oral vascular
tumors: 30 cases with histological diagnosis of HEM and 30 cases of oral pyogenic
granuloma (PG). The results of this research showed that of the 30 lesions initially
classified as HEM, only 7 showed immuno-positivity for GLUT-1, remaining with the
initial diagnosis. The remaining 23 were reclassified as vascular malformation (VM)
(13 cases) and PG (10 cases). All cases in the sample with an initial diagnosis of PG
were negative for GLUT-1, demonstrating the accuracy of histological diagnosis of
these lesions. Concerning to the immunoexpression of HIF-1α, the Mann-Whitney test
revealed a statistically significant difference between the cases of GP and MV (p =
0.002), where the median of GP (m=78) was higher than the MV (m=53). Based on
these results, this study showed that a histological diagnosis alone is not always
sufficient for the correct diagnosis of oral HEM and that HIF-1α participates in the
pathogenesis of vascular lesions |
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