Herdabilidade de preditores do risco cardiovascular
genetic and environmental factors contribute to the development of cardiovascular risk and that influence can be differentiated by factors characteristic of each population, age and sex. Aim: To investigate the heritability of anthropometric and biochemical markers as predictors of cardiovascular ri...
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Gêmeos. Obesidade. Herança genética. Antropometria. Fatores bioquímicos Twins. Obesity. Genetic inheritance. Anthropometry. Biochemical factors CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA |
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Gêmeos. Obesidade. Herança genética. Antropometria. Fatores bioquímicos Twins. Obesity. Genetic inheritance. Anthropometry. Biochemical factors CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA Oliveira, Michelle Vasconcelos de Herdabilidade de preditores do risco cardiovascular |
| description |
genetic and environmental factors contribute to the development of
cardiovascular risk and that influence can be differentiated by factors characteristic of
each population, age and sex. Aim: To investigate the heritability of anthropometric
and biochemical markers as predictors of cardiovascular risk in men and women of
different age groups, using the method of twins. Methods: A sample of 88 subjects
and of these 52 children and adolescents (08-17 years old) 32 monozygotic (20
female and 12 male) and 20 dizygotic (12 female and 08 male) and 36 adults (18-28
years age) 24 monozygotic (08 female and 16 male) and 12 dizygotic (06 female and
06 male), living in the metropolitan region of Natal / RN, Brazil. Anthropometric
measures were taken as the height, body mass, waist circumference (WC), sum of
skinfolds (ΣDC), fat percentage CUN-BAE, BMI and conicity. Biochemical markers
analyzed were: fasting glucose (GLU), total cholesterol (COL), HDL-C, LDL-C and
triglycerides (TG). After processing the data the index of heritability (h2) = (S ² MZ) / S
² DZ (DZ S ²) X100 was applied disaggregated by sex and age. Results: The
variables showed differential heritability of behavior for men and women, depending
on age. The variables with the highest heritability values were ΣDC, GLU, HDL, TG, in
men and BMI, WC, ΣDC, GLU, HDL-C and TG in women. And more influenced by the
environment variables were: body mass, BMI, Chol, LDL-C in men; body mass and
LDL-C in women. Conclusion: Differences index of heritability by gender for
cardiovascular risk predictors may assist in planning specific intervention strategies
according to gender and stage of life of that individual. It is from the level of
environmental influence that can run interventions for changes of components related
to cardiovascular risk |
| author2 |
Lemos, Telma Maria Araujo Moura |
| author_facet |
Lemos, Telma Maria Araujo Moura Oliveira, Michelle Vasconcelos de |
| format |
masterThesis |
| author |
Oliveira, Michelle Vasconcelos de |
| author_sort |
Oliveira, Michelle Vasconcelos de |
| title |
Herdabilidade de preditores do risco cardiovascular |
| title_short |
Herdabilidade de preditores do risco cardiovascular |
| title_full |
Herdabilidade de preditores do risco cardiovascular |
| title_fullStr |
Herdabilidade de preditores do risco cardiovascular |
| title_full_unstemmed |
Herdabilidade de preditores do risco cardiovascular |
| title_sort |
herdabilidade de preditores do risco cardiovascular |
| publisher |
Universidade Federal do Rio Grande do Norte |
| publishDate |
2014 |
| url |
https://repositorio.ufrn.br/jspui/handle/123456789/14620 |
| work_keys_str_mv |
AT oliveiramichellevasconcelosde herdabilidadedepreditoresdoriscocardiovascular |
| _version_ |
1773959369950494720 |
| spelling |
ri-123456789-146202017-10-31T18:45:02Z Herdabilidade de preditores do risco cardiovascular Oliveira, Michelle Vasconcelos de Lemos, Telma Maria Araujo Moura http://lattes.cnpq.br/5402923122245427 http://lattes.cnpq.br/4311626091295357 Dantas, Paulo Moreira Silva http://lattes.cnpq.br/0392766010188739 Cabral, Breno Guilherme de Araújo Tinôco http://lattes.cnpq.br/8399135324397066 Santos, Luciano Alonso Valente dos http://lattes.cnpq.br/9017927437502071 Gêmeos. Obesidade. Herança genética. Antropometria. Fatores bioquímicos Twins. Obesity. Genetic inheritance. Anthropometry. Biochemical factors CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA genetic and environmental factors contribute to the development of cardiovascular risk and that influence can be differentiated by factors characteristic of each population, age and sex. Aim: To investigate the heritability of anthropometric and biochemical markers as predictors of cardiovascular risk in men and women of different age groups, using the method of twins. Methods: A sample of 88 subjects and of these 52 children and adolescents (08-17 years old) 32 monozygotic (20 female and 12 male) and 20 dizygotic (12 female and 08 male) and 36 adults (18-28 years age) 24 monozygotic (08 female and 16 male) and 12 dizygotic (06 female and 06 male), living in the metropolitan region of Natal / RN, Brazil. Anthropometric measures were taken as the height, body mass, waist circumference (WC), sum of skinfolds (ΣDC), fat percentage CUN-BAE, BMI and conicity. Biochemical markers analyzed were: fasting glucose (GLU), total cholesterol (COL), HDL-C, LDL-C and triglycerides (TG). After processing the data the index of heritability (h2) = (S ² MZ) / S ² DZ (DZ S ²) X100 was applied disaggregated by sex and age. Results: The variables showed differential heritability of behavior for men and women, depending on age. The variables with the highest heritability values were ΣDC, GLU, HDL, TG, in men and BMI, WC, ΣDC, GLU, HDL-C and TG in women. And more influenced by the environment variables were: body mass, BMI, Chol, LDL-C in men; body mass and LDL-C in women. Conclusion: Differences index of heritability by gender for cardiovascular risk predictors may assist in planning specific intervention strategies according to gender and stage of life of that individual. It is from the level of environmental influence that can run interventions for changes of components related to cardiovascular risk Os fatores genéticos e ambientais contribuem para o desenvolvimento do risco cardiovascular e essa influência pode ser diferenciada por fatores característicos de cada população, idade e sexo. Objetivo: investigar a herdabilidade de variáveis antropométricas e marcadores bioquímicos como preditores do risco cardiovascular em homens e mulheres de diferentes faixas etárias, utilizando o método de gêmeos. Métodos: Amostra composta por 130 gêmeos, sendo do sexo feminino 42 monozigotos e 32 dizigotos e do sexo masculino 28 monozigotos e 28 dizigotos, residentes na região metropolitana de Natal/RN, Brasil. Como medidas antropométricas foram aferidas a estatura, massa corporal, circunferência da cintura (CC), somatório de dobras cutâneas (∑DC), percentual de gordura CUN-BAE, IMC e índice de conicidade. Os marcadores bioquímicos analisados foram: glicemia de jejum (GLI), colesterol total (COL), HDL-C, LDL-C e triglicerídeos (TG). Após o tratamento dos dados foi aplicado o índice de herdabilidade (h2) = ((S² DZ S² MZ) / S² DZ) x 100; separado por sexo e idade. Resultados: As variáveis apresentaram comportamento de hereditariedade diferenciado para homens e mulheres, dependendo da idade. As variáveis com maior herdabilidade foram: ∑DC, GLI, HDL, TG, nos homens; e IMC, CC, ∑DC, GLI, HDL-C e TG nas mulheres. E as variáveis mais influenciadas pelo ambiente foram: Massa, IMC, COL, LDL-C, nos homens; massa e LDL-C nas mulheres. Conclusão: As diferenças por sexo do índice de herdabilidade para os preditores do risco cardiovascular podem auxiliar no planejamento de estratégias de intervenção específicas de acordo com o sexo e estágio da vida desse indivíduo. É a partir do nível de influência ambiental que poderá correr as intervenções para modificações dos componentes relacionados ao risco cardiovascular 2014-12-17T14:44:18Z 2014-06-11 2014-12-17T14:44:18Z 2013-12-11 masterThesis OLIVEIRA, Michelle Vasconcelos de. Herdabilidade de preditores do risco cardiovascular. 2013. 130 f. Dissertação (Mestrado em Movimento Humano, Cultura e Educação, Saúde e Desempenho) - Universidade Federal do Rio Grande do Norte, Natal, 2013. https://repositorio.ufrn.br/jspui/handle/123456789/14620 por Acesso Aberto application/pdf application/pdf Universidade Federal do Rio Grande do Norte BR UFRN Programa de Pós-Graduação em Educação Física Movimento Humano, Cultura e Educação, Saúde e Desempenho |