Caracterização térmica (TG/DTG, DTA, DSC, DSC-fotovisual) de Hormônios bioidênticos (estriol estradiol)
Bioidentical hormones are defined as compounds that have exactly the same chemical and molecular structure as hormones that are produced in the human body. It is believed that the use of hormones may be safer and more effective than the non-bioidentical hormones, because binding to receptors in t...
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| Formato: | Dissertação |
| Idioma: | por |
| Publicado em: |
Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/13478 |
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| Resumo: | Bioidentical hormones are defined as compounds that have exactly the same chemical
and molecular structure as hormones that are produced in the human body. It is believed
that the use of hormones may be safer and more effective than the non-bioidentical
hormones, because binding to receptors in the organism would be similar to the
endogenous hormone. Bioidentical estrogens have been used in menopausal women, as
an alternative to traditional hormone replacement therapy. Thermal data of these
hormones are scarce in literature. Thermal analysis comprises a group of techniques that
allows evaluating the physical-chemistry properties of a drug, while the drug is subjected
to a controlled temperature programming. The thermal techniques are used in
pharmaceutical studies for characterization of drugs, purity determination, polymorphism
identification, compatibility and evaluation of stability. This study aims to characterize the
bioidentical hormones estradiol and estriol through thermal techniques TG/DTG, DTA,
DSC, DSC-photovisual. By the TG curves analysis was possible to calculated kinetic
parameters for the samples. The kinetic data showed that there is good correlation in the
different models used. For both estradiol and estriol, was found zero order reaction, which
enabled the construction of the vapor pressure curves. Data from DTA and DSC curves of
melting point and purity are the same of literature, showed relation with DSC-photovisual
results. The analysis DTA curves showed the fusion event had the best linearity for both
hormones. In the evaluation of possible degradation products, the analysis of the infrared
shows no degradation products in the solid state |
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