Determinação de parâmetros de qualidade para formas farmacêuticas homeopáticas
All medicine, whether allopathic or homeopathic, must go through strict quality control, which must ratify their characteristics throughout the period of validity. During the time of preparation and storage, solutions of the drugs are in permanent contact with packaging materials that can release...
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| Formato: | Dissertação |
| Idioma: | por |
| Publicado em: |
Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/13466 |
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| Resumo: | All medicine, whether allopathic or homeopathic, must go through strict quality
control, which must ratify their characteristics throughout the period of validity. During
the time of preparation and storage, solutions of the drugs are in permanent contact
with packaging materials that can release undesirable substances to the solution.
Several factors may influence the release of packing materials, and factorial design
(FD) is a useful tool for analyzing the phenomenon. The aim of this study was the
determination of quality parameters for Homeopathic solid (globules) and liquid
(drops) dosage forms. It was carried out analysis in homeopathic globules for weight
variation, mechanical strength, and moisture content uniformity. For liquid
preparations, standard solutions were prepared from natural rubber bulbs, which
were subjected to exhaustive extraction with two ethanol solutions (30 and 70%) in
the ultrasonic bath for 20 minutes at 25°C and 50°C in three successive cycles.
Studies of transfer have been made within five days, by spectrophotometric analysis
in the UV region at 312 nm with λmáx and 323 nm for samples in 70% ethanol and
30% respectively. PH values were analyzed. We also conducted two FD studies,
where the first, the three-level variables were solvent (chloroform, ethanol and nhexane),
sample mass (30, 60 and 90mg), particle size (large disk, small disk and
powder sample). In the second study, the solvent level variables were different
ethanolic degrees (EtOH 30%, 70% and pure). The percentage of lending in the
solutions was 5.5%, 12.4%, 24.2% and 41% of the total estimated in the reference
solution. The values of rate constants of transfer were determined in the order of
0.0134 days-1 and 0.0232 days-1 in absorbance values, the solutions in ethanol at
30% and 70% respectively. These results suggest that the speed of transfer of
materials from rubber is affected both by the nature of the vehicle as by the
temperature |
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