Consequências da colectomia associada à hepatectomia no metabolismo hepático e na forma e função de hemácias em ratos
This study investigated the influence of partial colectomy associated with hepatectomy on the biodistribution of the 99mTc-phytate, on metabolic parameters, as well as labeling and morphology of red blood cells. Wistar rats were distributed into three groups (each with 6), nominated as colectomy,...
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| Formato: | Dissertação |
| Idioma: | por |
| Publicado em: |
Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/13395 |
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| Resumo: | This study investigated the influence of partial colectomy associated with
hepatectomy on the biodistribution of the 99mTc-phytate, on metabolic parameters, as
well as labeling and morphology of red blood cells. Wistar rats were distributed into
three groups (each with 6), nominated as colectomy, colectomy+hepatectomy and
sham. In the 30th postoperative day all rats were injected with 99mTc-phytate 0.1mL
i.v. (radioactivity 0.66 MBq). After 15 minutes, liver sample was harvested and
weighed. Percentage radioactivity per gram of tissue (%ATI/g) was determined using
an automatic gamma-counter. Serum AST, ALT, alkaline phosphatase and red blood
cells labeling were determined. The liver %ATI/g and red blood cells labeling were
lower in colectomy and colectomy+hepatectomy rats than in sham rats (p <0.05), and
no difference was detected comparing the colectomy and colectomy+hepatectomy
groups. Red blood cells morphology did not differ among groups. Serum levels of
AST, ALT and alkaline fosfatase were significantly higher in colectomy+hepatectomy
than in colectomy rats (p<0.001). Hepatectomy associated with colectomy lowered
the uptake of radiopharmaceutical in liver and in red blood cells in rats, coinciding
with changes in liver enzymatic activity |
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