Efeito sacietogênico de um novo inibidor de tripsina da paçoca do amendoim com aumento plasmático de colecistocinina (cck)
Obesity is increasing, reaching epidemic levels in many regions of the world. Studies have shown that consumption of peanuts influences on weight control and this influence may be due to the action of trypsin inhibitors sacietogênica that condition increased plasma colescistocinina (CCK). Moreove...
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Formato: | Dissertação |
Idioma: | por |
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Universidade Federal do Rio Grande do Norte
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Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/12601 |
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Resumo: | Obesity is increasing, reaching epidemic levels in many regions of the world. Studies
have shown that consumption of peanuts influences on weight control and this
influence may be due to the action of trypsin inhibitors sacietogênica that condition
increased plasma colescistocinina (CCK). Moreover, the peanut has other health
benefits, and these assignments are guaranteed to increase their production and
consumption of several of its products, including the paçoca peanut. The aim of this
study was to identify the presence of a trypsin inhibitor in paçoca peanut and
evaluate its effect on food intake, weight gain and histomorphological changes in
swiss mice (n = 8) and Wistar rats (n = 6). Experimental diets were prepared based
on the AIN-93G and supplemented with tack or peanut trypsin inhibitor partially
purified paçoca peanut (AHTI). After each treatment, the animals were anesthetized
and euthanized, their bloods were collected by cardiac puncture for the determination
of CCK and other biochemical parameters (glucose, triglycerides, total cholesterol,
high density lipoprotein, low density lipoprotein, glutamic-pyruvic transaminase,
glutamic oxaloacetic transaminase and albumin) and their pancreas removed for
histologic and morphometric analysis. The supplementation with paçoca peanut and
the AHTI showed a decrease of body weight gain and food intake in both mice and
rats, due to the satiety, since the animals showed no evidence of impairment of
nutritional status conditioned by consumption the AHTI. There were also observed
biochemical or morphological important when compared with controls. However,
AHTI led to increased secretion of CCK, a peptide sacietogênico. Thus, these results
indicate that AHTI present in paçoca peanut, is able to enhance the secretion of
plasma CCK and thereby reduce the weight gain associated with lower food intake of
experimenta animals |
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