Efeito do estado nutricional bioquímico de retinol e alfatocoferol sobre seus níveis em lactantes
Vitamins A and E are essential nutrients in many biological processes, so that their adequate supply to the neonate is crucial. However, the bioavailability of vitamins may be limited by factors such as maternal nutritional status and the interaction between nutrients. This study aimed to investi...
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| Formato: | Dissertação |
| Idioma: | por |
| Publicado em: |
Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/12581 |
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| Resumo: | Vitamins A and E are essential nutrients in many biological processes, so that their
adequate supply to the neonate is crucial. However, the bioavailability of vitamins
may be limited by factors such as maternal nutritional status and the interaction
between nutrients. This study aimed to investigate the effect of biochemical
nutritional status of retinol and alpha-tocopherol levels in serum and colostrum. The
study included 103 healthy puerperal women treated at the reference state maternity
hospital (Natal-RN). Colostrum and serum samples were collected fasting in the
immediate postpartum period and the analysis of retinol and alpha-tocopherol were
determined by high-performance liquid chromatography. Specific cutoff points were
adopted to characterize the biochemical status of vitamins A and E. For the total
group of lactanting women the average concentration of retinol in serum (1.49 ± 0.4
μmol/L-1) and colostrum (2.18 ± 0.8 μmol/L-1), as well as alpha-tocopherol in serum
(26.4 ± 8.0 μmol/L-1) and colostrum (26.1 ± 12.8 μmol/L-1), indicated adequate
biochemical state. However, when evaluating the individual, was found a high
prevalence of deficient serum (15%) and colostrum retinol (50%), and also alphatocopherol
in serum (16%) and colostrum (61%). In women with serum retinol ≥ 1.05
μmol/L-1, found an inverse correlation between serum retinol and alpha-tocopherol in
colostrum (p = 0.008, r = -0.28). This association was not observed in women with
serum retinol <1.05 μmol/L-1. This situation demonstrates for the first time in humans
that high physiological levels of serum retinol, without supplementation, can
negatively influence the transfer of alpha-tocopherol in breast milk. Although the
diagnosis of satisfactory nutritional status lactanting women showed high risk of
subclinical deficiency of vitamins A and E from measurements made in the colostrum |
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