Prevention of bacterial translocation using β-(1-3)-D-glucan in small bowel ischemia and reperfusion in rats
To investigate the role of β-(1-3)-D-glucan on 99mTc labelled Escherichia coli translocation and cytokines secretion in rats submitted to small bowel ischemia/reperfusion injury. Methods: Five groups (n=10 each) of Wistar rats were subjected to control(C), sham(S), group IR subjected to 45 min of...
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ri-1-66172021-11-30T19:25:03Z Prevention of bacterial translocation using β-(1-3)-D-glucan in small bowel ischemia and reperfusion in rats Prevenção de translocação bacteriana com β-(1-3)-D-glucana em isquemia e reperfusão intestinal em ratos Araújo Filho, Irami Rêgo, Amália Cínthia Meneses Pinheiro, Laíza Araújo Mohana Azevedo, Italo Medeiros Medeiros, Vítor Brasil Brandão Neto, José Medeiros, Aldo Cunha Bacterial translocation Glucan Intestine Ischemia Reperfusion Prophylaxis To investigate the role of β-(1-3)-D-glucan on 99mTc labelled Escherichia coli translocation and cytokines secretion in rats submitted to small bowel ischemia/reperfusion injury. Methods: Five groups (n=10 each) of Wistar rats were subjected to control(C), sham(S), group IR subjected to 45 min of bowel ischemia/60 min of reperfusion(I/R), and group I/R+glucan subjected to 45 min of bowel ischemia/60 min of reperfusion(I/R) and injected with 2mg/Kg intramuscular. Translocation of labelled bacteria to mesenteric lymph nodes, liver, spleen, lung and serum was determined using radioactivity/count and colony forming units/g(CFU/g). Serum TNFα, IL-1β, IL-6, IL-10 were measured by ELISA. Results: CFU/g and radioactivity/count were higher in I/R than in I/R+glucan rats. In C, S and S+glucan groups, bacteria and radioactivity/count were rarely detected. The I/R+glucan rats had enhancement of IL-10 and suppressed production of serum TNFα, IL-1β and, IL-6, compared to I/R untreated animals. Conclusion: The β-(1-3)-D-glucan modulated the production of pro-inflammatory and anti-inflammatory cytokines during bowel ischemia/reperfusion, and attenuated translocation of labelled bacteria CNPq 2013-10-21T18:19:22Z 2013-10-21T18:19:22Z 2006 article ARAÚJO FILHO, Irami; RÊGO, Amália Cínthia Meneses; PINHEIRO, Laíza Araújo Mohana; AZEVEDO, Italo Medeiros; MEDEIROS, Vítor Brasil; BRANDÃO NETO, José; MEDEIROS, Aldo Cunha. Prevention of bacterial translocation using beta-(1-3)-D-glucan in small bowel ischemia and reperfusion in rats. Acta Cirúrgica Brasileira , v. 21, p. 18-22, 2006. Disponível em: <http://www.scielo.br/scielo.php?pid=S0102-86502006001000005&script=sci_arttext> Acesso em: 09 out. 2013. 1678-2674 https://repositorio.ufrn.br/jspui/handle/1/6617 eng Acesso Aberto application/pdf |
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Bacterial translocation Glucan Intestine Ischemia Reperfusion Prophylaxis |
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Bacterial translocation Glucan Intestine Ischemia Reperfusion Prophylaxis Araújo Filho, Irami Rêgo, Amália Cínthia Meneses Pinheiro, Laíza Araújo Mohana Azevedo, Italo Medeiros Medeiros, Vítor Brasil Brandão Neto, José Medeiros, Aldo Cunha Prevention of bacterial translocation using β-(1-3)-D-glucan in small bowel ischemia and reperfusion in rats |
description |
To investigate the role of β-(1-3)-D-glucan on 99mTc labelled Escherichia coli translocation and cytokines
secretion in rats submitted to small bowel ischemia/reperfusion injury. Methods: Five groups (n=10 each) of Wistar rats
were subjected to control(C), sham(S), group IR subjected to 45 min of bowel ischemia/60 min of reperfusion(I/R), and
group I/R+glucan subjected to 45 min of bowel ischemia/60 min of reperfusion(I/R) and injected with 2mg/Kg intramuscular.
Translocation of labelled bacteria to mesenteric lymph nodes, liver, spleen, lung and serum was determined using
radioactivity/count and colony forming units/g(CFU/g). Serum TNFα, IL-1β, IL-6, IL-10 were measured by ELISA. Results:
CFU/g and radioactivity/count were higher in I/R than in I/R+glucan rats. In C, S and S+glucan groups, bacteria and
radioactivity/count were rarely detected. The I/R+glucan rats had enhancement of IL-10 and suppressed production of
serum TNFα, IL-1β and, IL-6, compared to I/R untreated animals. Conclusion: The β-(1-3)-D-glucan modulated the
production of pro-inflammatory and anti-inflammatory cytokines during bowel ischemia/reperfusion, and attenuated
translocation of labelled bacteria |
format |
article |
author |
Araújo Filho, Irami Rêgo, Amália Cínthia Meneses Pinheiro, Laíza Araújo Mohana Azevedo, Italo Medeiros Medeiros, Vítor Brasil Brandão Neto, José Medeiros, Aldo Cunha |
author_facet |
Araújo Filho, Irami Rêgo, Amália Cínthia Meneses Pinheiro, Laíza Araújo Mohana Azevedo, Italo Medeiros Medeiros, Vítor Brasil Brandão Neto, José Medeiros, Aldo Cunha |
author_sort |
Araújo Filho, Irami |
title |
Prevention of bacterial translocation using β-(1-3)-D-glucan in small bowel ischemia and reperfusion in rats |
title_short |
Prevention of bacterial translocation using β-(1-3)-D-glucan in small bowel ischemia and reperfusion in rats |
title_full |
Prevention of bacterial translocation using β-(1-3)-D-glucan in small bowel ischemia and reperfusion in rats |
title_fullStr |
Prevention of bacterial translocation using β-(1-3)-D-glucan in small bowel ischemia and reperfusion in rats |
title_full_unstemmed |
Prevention of bacterial translocation using β-(1-3)-D-glucan in small bowel ischemia and reperfusion in rats |
title_sort |
prevention of bacterial translocation using β-(1-3)-d-glucan in small bowel ischemia and reperfusion in rats |
publishDate |
2013 |
url |
https://repositorio.ufrn.br/jspui/handle/1/6617 |
work_keys_str_mv |
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