Effect of simvastatin on coagulation in rats with abdominal sepsis

Objective: This study aimed to evaluate the Simvastatin pleiotropic effects in coagulation on rats with abdominal sepis. Methods: Twelve Wistar rats (three months, 273-297g) were randomly assigned to abdominal septic group (n=6), induced by cecal ligation and pucture (CLP) and septic group with a pr...

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Главные авторы: Medeiros, Aldo Cunha, Araújo-Filho, Irami, Tavares, Camila Carlos, Mota, Nathalia Louise R Alves, Rêgo, Amália Cinthia Meneses, Azevedo, Ítalo Medeiros de, Medeiros, Vanessa de Fátima Lima Paiva
Формат: Online
Язык:eng
Опубликовано: FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
Online-ссылка:https://periodicos.ufrn.br/jscr/article/view/3569
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spelling oai:periodicos.ufrn.br:article-35692019-06-05T23:31:27Z Effect of simvastatin on coagulation in rats with abdominal sepsis Medeiros, Aldo Cunha Araújo-Filho, Irami Tavares, Camila Carlos Mota, Nathalia Louise R Alves Rêgo, Amália Cinthia Meneses Azevedo, Ítalo Medeiros de Medeiros, Vanessa de Fátima Lima Paiva Coagulation Sepsis Peritonitis Simvastatin Objective: This study aimed to evaluate the Simvastatin pleiotropic effects in coagulation on rats with abdominal sepis. Methods: Twelve Wistar rats (three months, 273-297g) were randomly assigned to abdominal septic group (n=6), induced by cecal ligation and pucture (CLP) and septic group with a previous drug treatment (n=6). The Simvastatin/CLP group was treated with oral simvastatin (10 mg/Kg), eighteen and two hours before the CLP procedure or normal saline solution 0.9%. Peripheral blood laboratory determinations: Platelets, ativated troboplastin parcial time, activated coagulation time, protrombin time, trombin time, fibrinogen dosage, factor VII and factor VIII. Statistical analysis was done by ANOVA and Tukey test, with p<0.05. Results: It wasn’t found any significant statistic differences between the groups. Conclusion: Simvastatin did not change the coagulation in rats with abdominal sepsis, according to this experimental model. FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL 2013-06-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://periodicos.ufrn.br/jscr/article/view/3569 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; Vol. 3 No. 2 (2012); 68-74 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; v. 3 n. 2 (2012); 68-74 2179-7889 eng https://periodicos.ufrn.br/jscr/article/view/3569/2848 Copyright (c) 2014 JOURNAL OF SURGICAL AND CLINICAL RESEARCH
institution Periódicos UFRN
collection Portal de Pediódicos Eletrônicos da UFRN
language eng
format Online
author Medeiros, Aldo Cunha
Araújo-Filho, Irami
Tavares, Camila Carlos
Mota, Nathalia Louise R Alves
Rêgo, Amália Cinthia Meneses
Azevedo, Ítalo Medeiros de
Medeiros, Vanessa de Fátima Lima Paiva
spellingShingle Medeiros, Aldo Cunha
Araújo-Filho, Irami
Tavares, Camila Carlos
Mota, Nathalia Louise R Alves
Rêgo, Amália Cinthia Meneses
Azevedo, Ítalo Medeiros de
Medeiros, Vanessa de Fátima Lima Paiva
Effect of simvastatin on coagulation in rats with abdominal sepsis
author_facet Medeiros, Aldo Cunha
Araújo-Filho, Irami
Tavares, Camila Carlos
Mota, Nathalia Louise R Alves
Rêgo, Amália Cinthia Meneses
Azevedo, Ítalo Medeiros de
Medeiros, Vanessa de Fátima Lima Paiva
author_sort Medeiros, Aldo Cunha
title Effect of simvastatin on coagulation in rats with abdominal sepsis
title_short Effect of simvastatin on coagulation in rats with abdominal sepsis
title_full Effect of simvastatin on coagulation in rats with abdominal sepsis
title_fullStr Effect of simvastatin on coagulation in rats with abdominal sepsis
title_full_unstemmed Effect of simvastatin on coagulation in rats with abdominal sepsis
title_sort effect of simvastatin on coagulation in rats with abdominal sepsis
description Objective: This study aimed to evaluate the Simvastatin pleiotropic effects in coagulation on rats with abdominal sepis. Methods: Twelve Wistar rats (three months, 273-297g) were randomly assigned to abdominal septic group (n=6), induced by cecal ligation and pucture (CLP) and septic group with a previous drug treatment (n=6). The Simvastatin/CLP group was treated with oral simvastatin (10 mg/Kg), eighteen and two hours before the CLP procedure or normal saline solution 0.9%. Peripheral blood laboratory determinations: Platelets, ativated troboplastin parcial time, activated coagulation time, protrombin time, trombin time, fibrinogen dosage, factor VII and factor VIII. Statistical analysis was done by ANOVA and Tukey test, with p<0.05. Results: It wasn’t found any significant statistic differences between the groups. Conclusion: Simvastatin did not change the coagulation in rats with abdominal sepsis, according to this experimental model.
publisher FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
publishDate 2013
url https://periodicos.ufrn.br/jscr/article/view/3569
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