Effect of simvastatin on coagulation in rats with abdominal sepsis
Objective: This study aimed to evaluate the Simvastatin pleiotropic effects in coagulation on rats with abdominal sepis. Methods: Twelve Wistar rats (three months, 273-297g) were randomly assigned to abdominal septic group (n=6), induced by cecal ligation and pucture (CLP) and septic group with a pr...
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| Principais autores: | , , , , , , |
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| Formato: | Online |
| Idioma: | eng |
| Publicado em: |
FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
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| Endereço do item: | https://periodicos.ufrn.br/jscr/article/view/3569 |
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| Resumo: | Objective: This study aimed to evaluate the Simvastatin pleiotropic effects in coagulation on rats with abdominal sepis. Methods: Twelve Wistar rats (three months, 273-297g) were randomly assigned to abdominal septic group (n=6), induced by cecal ligation and pucture (CLP) and septic group with a previous drug treatment (n=6). The Simvastatin/CLP group was treated with oral simvastatin (10 mg/Kg), eighteen and two hours before the CLP procedure or normal saline solution 0.9%. Peripheral blood laboratory determinations: Platelets, ativated troboplastin parcial time, activated coagulation time, protrombin time, trombin time, fibrinogen dosage, factor VII and factor VIII. Statistical analysis was done by ANOVA and Tukey test, with p<0.05. Results: It wasn’t found any significant statistic differences between the groups. Conclusion: Simvastatin did not change the coagulation in rats with abdominal sepsis, according to this experimental model. |
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