Healing of wounds in diabetic rats treated with Rosa rubiginosa oil

PURPOSE: This study aimed to examine if Rosa rubiginosa oil (Rro) influences the healing of skin wounds of diabetic rats. METHODS: Four groups of Wistar rats were used (6 rats/group). Group 1: skin wounds were topically treated with normal saline (NS). Group 2 had skin wounds treated with Rro for 10...

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Principais autores: Nascimento, Isadora, Pinheiro Gomes, Maria Eduarda Pinheiro Gomes, Gomes Fernandes, Naíla Esther, Medeiros Azevedo, Ítalo, de Alcântara Oliveira Ramalho Borges, Rachel, Cunha Medeiros, Aldo
Formato: Online
Idioma:eng
Publicado em: FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
Endereço do item:https://periodicos.ufrn.br/jscr/article/view/31122
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spelling oai:periodicos.ufrn.br:article-311222023-08-26T20:04:18Z Healing of wounds in diabetic rats treated with Rosa rubiginosa oil Cicatrização de feridas em ratos diabéticos tratados com óleo de Rosa rubiginosa Nascimento, Isadora Pinheiro Gomes, Maria Eduarda Pinheiro Gomes Gomes Fernandes, Naíla Esther Medeiros Azevedo, Ítalo de Alcântara Oliveira Ramalho Borges, Rachel Cunha Medeiros, Aldo Wound healing Diabetes induction Rosa rubiginosa Oil Rats PURPOSE: This study aimed to examine if Rosa rubiginosa oil (Rro) influences the healing of skin wounds of diabetic rats. METHODS: Four groups of Wistar rats were used (6 rats/group). Group 1: skin wounds were topically treated with normal saline (NS). Group 2 had skin wounds treated with Rro for 10 days. Diabetes was induced with Streptozotocin (STZ) in groups 3 and 4. Group 3 had the wounds treated with NS. The wounds of groups 4 were treated with Rro. After anesthesia, all rats had skin excisional wounds 0.8 cm diameter. On 10th day, blood glucose and wound tissue cytokines were measured. Histometry of wounds was studied. RESULTS: Glycemia levels of 3 an 4 group rats were >250 mg%. Diabetic and non diabetic rats treated with Rro had wound tissue TNF-α, IL-1β and IL-6 expression lower than in rats receiving NS.  The histological inflammatory score of  Rro treated diabetic rats (19±2.7) was significantly higher than in rats treatment with NS (14±2.5). CONCLUSION: The topical treatment of skin wounds in  diabetic rats with Rosa rubiginosa oil positively influenced the healing. OBJETIVO: Este estudo teve como objetivo verificar se o óleo de Rosa rubiginosa (Rro) influencia na cicatrização de feridas cutâneas de ratos diabéticos. MÉTODOS: Foram utilizados quatro grupos de ratos Wistar (6 ratos/grupo). Grupo 1: as feridas cutâneas foram tratadas topicamente com solução salina normal (NS). O grupo 2 teve feridas cutâneas tratadas com Rro por 10 dias. O diabetes foi induzido com estreptozotocina (STZ) nos grupos 3 e 4. O grupo 3 teve as feridas tratadas com NS. As feridas dos grupos 4 foram tratadas com Rro. Após a anestesia, todos os ratos tiveram feridas excisionais na pele de 0,8 cm de diâmetro. No 10º dia, a glicemia e as citocinas do tecido da ferida foram medidas. A histometria das feridas foi estudada. RESULTADOS: Os níveis de glicemia dos ratos dos grupos 3 e 4 foram >250 mg%. Ratos diabéticos e não diabéticos tratados com Rro apresentaram expressão tecidual de TNF-α, IL-1β e IL-6 menor do que em ratos recebendo SN. O escore inflamatório histológico de ratos diabéticos tratados com Rro (19±2,7) ​​foi significativamente maior do que em ratos tratados com SN (14±2,5). CONCLUSÃO: O tratamento tópico de feridas cutâneas em ratos diabéticos com óleo de Rosa rubiginosa influenciou positivamente na cicatrização. FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL 2023-02-05 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://periodicos.ufrn.br/jscr/article/view/31122 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; Vol. 13 No. 2 (2022); 38-49 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; v. 13 n. 2 (2022); 38-49 2179-7889 eng https://periodicos.ufrn.br/jscr/article/view/31122/16702 Copyright (c) 2023 JOURNAL OF SURGICAL AND CLINICAL RESEARCH http://creativecommons.org/licenses/by-nc-sa/4.0
institution Periódicos UFRN
collection Portal de Pediódicos Eletrônicos da UFRN
language eng
format Online
author Nascimento, Isadora
Pinheiro Gomes, Maria Eduarda Pinheiro Gomes
Gomes Fernandes, Naíla Esther
Medeiros Azevedo, Ítalo
de Alcântara Oliveira Ramalho Borges, Rachel
Cunha Medeiros, Aldo
spellingShingle Nascimento, Isadora
Pinheiro Gomes, Maria Eduarda Pinheiro Gomes
Gomes Fernandes, Naíla Esther
Medeiros Azevedo, Ítalo
de Alcântara Oliveira Ramalho Borges, Rachel
Cunha Medeiros, Aldo
Healing of wounds in diabetic rats treated with Rosa rubiginosa oil
author_facet Nascimento, Isadora
Pinheiro Gomes, Maria Eduarda Pinheiro Gomes
Gomes Fernandes, Naíla Esther
Medeiros Azevedo, Ítalo
de Alcântara Oliveira Ramalho Borges, Rachel
Cunha Medeiros, Aldo
author_sort Nascimento, Isadora
title Healing of wounds in diabetic rats treated with Rosa rubiginosa oil
title_short Healing of wounds in diabetic rats treated with Rosa rubiginosa oil
title_full Healing of wounds in diabetic rats treated with Rosa rubiginosa oil
title_fullStr Healing of wounds in diabetic rats treated with Rosa rubiginosa oil
title_full_unstemmed Healing of wounds in diabetic rats treated with Rosa rubiginosa oil
title_sort healing of wounds in diabetic rats treated with rosa rubiginosa oil
description PURPOSE: This study aimed to examine if Rosa rubiginosa oil (Rro) influences the healing of skin wounds of diabetic rats. METHODS: Four groups of Wistar rats were used (6 rats/group). Group 1: skin wounds were topically treated with normal saline (NS). Group 2 had skin wounds treated with Rro for 10 days. Diabetes was induced with Streptozotocin (STZ) in groups 3 and 4. Group 3 had the wounds treated with NS. The wounds of groups 4 were treated with Rro. After anesthesia, all rats had skin excisional wounds 0.8 cm diameter. On 10th day, blood glucose and wound tissue cytokines were measured. Histometry of wounds was studied. RESULTS: Glycemia levels of 3 an 4 group rats were >250 mg%. Diabetic and non diabetic rats treated with Rro had wound tissue TNF-α, IL-1β and IL-6 expression lower than in rats receiving NS.  The histological inflammatory score of  Rro treated diabetic rats (19±2.7) was significantly higher than in rats treatment with NS (14±2.5). CONCLUSION: The topical treatment of skin wounds in  diabetic rats with Rosa rubiginosa oil positively influenced the healing.
publisher FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
publishDate 2023
url https://periodicos.ufrn.br/jscr/article/view/31122
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