Osteogenic potential of mesenchymal stem cells over-expression of bone morphogenetic protein 9

Bone tissue is composed of cells capable of tissue repair, remodeling and regeneration, but which, in large proportions, do not present satisfactory results. Thus, new therapies based on regenerative medicine using stem cells have been evaluated in order to solve the problem. The present study seeks...

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Principais autores: Sousa, Zildenilson da Silva, Moreira, Thales Peres Candido, Chaves Júnior, Perilo Marques, Matias, Ana Carolina da Silva, Santos, Valéria Pinto dos, Mateus, Moysés Matias, Marques, Débora Landim, Silva, Samara Evangelista da, Alves, José Rafael de Sá, Sá, Bruna Damasceno, Andrade, Michelle Carregosa
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Publicado em: Max Leandro de Araújo Brito
Endereço do item:https://periodicos.ufrn.br/casoseconsultoria/article/view/30285
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collection Portal de Pediódicos Eletrônicos da UFRN
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author Sousa, Zildenilson da Silva
Moreira, Thales Peres Candido
Chaves Júnior, Perilo Marques
Matias, Ana Carolina da Silva
Santos, Valéria Pinto dos
Mateus, Moysés Matias
Marques, Débora Landim
Silva, Samara Evangelista da
Alves, José Rafael de Sá
Sá, Bruna Damasceno
Andrade, Michelle Carregosa
spellingShingle Sousa, Zildenilson da Silva
Moreira, Thales Peres Candido
Chaves Júnior, Perilo Marques
Matias, Ana Carolina da Silva
Santos, Valéria Pinto dos
Mateus, Moysés Matias
Marques, Débora Landim
Silva, Samara Evangelista da
Alves, José Rafael de Sá
Sá, Bruna Damasceno
Andrade, Michelle Carregosa
Osteogenic potential of mesenchymal stem cells over-expression of bone morphogenetic protein 9
author_facet Sousa, Zildenilson da Silva
Moreira, Thales Peres Candido
Chaves Júnior, Perilo Marques
Matias, Ana Carolina da Silva
Santos, Valéria Pinto dos
Mateus, Moysés Matias
Marques, Débora Landim
Silva, Samara Evangelista da
Alves, José Rafael de Sá
Sá, Bruna Damasceno
Andrade, Michelle Carregosa
author_sort Sousa, Zildenilson da Silva
title Osteogenic potential of mesenchymal stem cells over-expression of bone morphogenetic protein 9
title_short Osteogenic potential of mesenchymal stem cells over-expression of bone morphogenetic protein 9
title_full Osteogenic potential of mesenchymal stem cells over-expression of bone morphogenetic protein 9
title_fullStr Osteogenic potential of mesenchymal stem cells over-expression of bone morphogenetic protein 9
title_full_unstemmed Osteogenic potential of mesenchymal stem cells over-expression of bone morphogenetic protein 9
title_sort osteogenic potential of mesenchymal stem cells over-expression of bone morphogenetic protein 9
description Bone tissue is composed of cells capable of tissue repair, remodeling and regeneration, but which, in large proportions, do not present satisfactory results. Thus, new therapies based on regenerative medicine using stem cells have been evaluated in order to solve the problem. The present study seeks to evaluate, through an integrative literature review, the bone formation potential of mesenchymal stem cells (MSC) over-expression of bone morphogenetic protein 9 (BMP-9). This is an exploratory, qualitative and descriptive study. For its idealization, the descriptors registered in the DeCS/MeSH “regeneration”, “mesenchymal stem cells”, “bone morphogenetic protein 9” and “growth differentiation factor 2” were linked using the Boolean operators “and” and “or” and applied to the databases from PubMed/Medline, Scielo, Bireme and Google Scholar. Of the 142 studies located in a time frame of 10 years (2012 to 2022), 12 articles published in English and Portuguese were included in the final sample. Among the results, in vitro and in vivo studies show the therapy as promising in the process of bone tissue formation. BMP-9 and CTM increased the differentiation potency of cells in the tissue, enabling the repair of extensive bone defects. Technological tools of gene editing have suggested great possibilities to revolutionize science, since they are guides for the cleavage of DNA. Future studies are needed with a focus on cell therapy, so that the applicability of this technique is scientifically deepened and can later advance to its clinical use in the health sciences.
publisher Max Leandro de Araújo Brito
publishDate 2023
url https://periodicos.ufrn.br/casoseconsultoria/article/view/30285
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spelling oai:periodicos.ufrn.br:article-302852023-04-25T02:38:25Z Osteogenic potential of mesenchymal stem cells over-expression of bone morphogenetic protein 9 Potencial osteogénico de células madre mesenquimales sobreexpresión de proteína morfogenética ósea 9 Potencial osteogênico de células-tronco mesenquimais sobre-expressão da proteína morfogenética óssea 9 Sousa, Zildenilson da Silva Moreira, Thales Peres Candido Chaves Júnior, Perilo Marques Matias, Ana Carolina da Silva Santos, Valéria Pinto dos Mateus, Moysés Matias Marques, Débora Landim Silva, Samara Evangelista da Alves, José Rafael de Sá Sá, Bruna Damasceno Andrade, Michelle Carregosa Regeneração Terapia celular Células-tronco mesenquimais Proteína Morfogenética Óssea Regeneration Cell therapy Mesenchymal stem cells Bone Morphogenetic Protein Regeneración Terapia celular Células madre mesenquimales Proteína morfogenética ósea Bone tissue is composed of cells capable of tissue repair, remodeling and regeneration, but which, in large proportions, do not present satisfactory results. Thus, new therapies based on regenerative medicine using stem cells have been evaluated in order to solve the problem. The present study seeks to evaluate, through an integrative literature review, the bone formation potential of mesenchymal stem cells (MSC) over-expression of bone morphogenetic protein 9 (BMP-9). This is an exploratory, qualitative and descriptive study. For its idealization, the descriptors registered in the DeCS/MeSH “regeneration”, “mesenchymal stem cells”, “bone morphogenetic protein 9” and “growth differentiation factor 2” were linked using the Boolean operators “and” and “or” and applied to the databases from PubMed/Medline, Scielo, Bireme and Google Scholar. Of the 142 studies located in a time frame of 10 years (2012 to 2022), 12 articles published in English and Portuguese were included in the final sample. Among the results, in vitro and in vivo studies show the therapy as promising in the process of bone tissue formation. BMP-9 and CTM increased the differentiation potency of cells in the tissue, enabling the repair of extensive bone defects. Technological tools of gene editing have suggested great possibilities to revolutionize science, since they are guides for the cleavage of DNA. Future studies are needed with a focus on cell therapy, so that the applicability of this technique is scientifically deepened and can later advance to its clinical use in the health sciences. El tejido óseo está compuesto por células capaces de reparar, remodelar y regenerar tejidos, pero que, en grandes proporciones, no presentan resultados satisfactorios. Así, se han evaluado nuevas terapias basadas en la medicina regenerativa con células madre para solucionar el problema. El presente estudio busca evaluar, a través de una revisión integrativa de la literatura, el potencial de formación ósea de la sobreexpresión de la proteína morfogenética ósea 9 (BMP-9) en células madre mesenquimales (MSC). Se trata de un estudio exploratorio, cualitativo y descriptivo. Para su idealización, los descriptores registrados en el DeCS/MeSH “regeneración”, “células madre mesenquimales”, “proteína morfogenética ósea 9” y “factor de diferenciación de crecimiento 2” se vincularon mediante los operadores booleanos “y” y “o” y se aplicaron a las bases de datos de PubMed/Medline, Scielo, Bireme y Google Scholar. De los 142 estudios ubicados en un marco temporal de 10 años (2012 a 2022), 12 artículos publicados en inglés y portugués fueron incluidos en la muestra final. Entre los resultados, estudios in vitro e in vivo muestran que la terapia es prometedora en el proceso de formación de tejido óseo. BMP-9 y CTM aumentaron la potencia de diferenciación de las células en el tejido, lo que permitió la reparación de defectos óseos extensos. Las herramientas tecnológicas de edición de genes han sugerido grandes posibilidades para revolucionar la ciencia, ya que son guías para la escisión del ADN. Son necesarios futuros estudios con enfoque en la terapia celular, para que se profundice científicamente la aplicabilidad de esta técnica y pueda avanzar posteriormente a su uso clínico en las ciencias de la salud. O tecido ósseo é composto por células capazes de reparação, remodelação e regeneração tecidual, mas que em grandes proporções não apresentam resultados satisfatórios. Assim, novas terapias baseadas na medicina regenerativa por meio de células-tronco vêm sendo avaliadas com o intuito de solucionar a problemática. O presente estudo busca avaliar, por meio de uma revisão integrativa da literatura, o potencial de formação óssea de células-tronco mesenquimais (CTM) sobre-expressão da proteína morfogenética óssea 9 (BMP-9). Trata-se de um estudo exploratório, qualitativo e descritivo. Para sua idealização, os descritores cadastrados no DeCS/MeSH “regeneration”, “mesenchymal stem cells”, “bone morphogenetic protein 9” e “growth differentiation factor 2” foram interligados por meio dos operadores booleanos “and” e “or” e aplicados nas bases de dados da PubMed/Medline, Scielo, Bireme e Google Acadêmico. Dos 142 estudos localizados em um recorte temporal de 10 anos (2012 a 2022), 12 artigos publicados na língua inglesa e portuguesa foram incluídos na amostragem final. Dentre os resultados, estudos in vitro e in vivo evidenciam a terapia como promissora no processo de formação de tecido ósseo.  BMP-9 e CTM aumentaram a potência de diferenciação de células no tecido, possibilitando o reparo em defeitos ósseos extensos. Ferramentas tecnológicas de edição genética têm sugerido grandes possibilidade de revolucionar a ciência, uma vez que são guias para a clivagem de DNA. Estudos futuros se fazem necessários com o enfoque na terapia celular, para que assim a aplicabilidade dessa técnica seja aprofundada cientificamente e posteriormente possa avançar para seu uso clínico nas ciências da saúde. Max Leandro de Araújo Brito 2023-04-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://periodicos.ufrn.br/casoseconsultoria/article/view/30285 Revista de Casos e Consultoria; v. 14 n. 1 (2023); e30285 2237-7417 por https://periodicos.ufrn.br/casoseconsultoria/article/view/30285/16870 Copyright (c) 2023 Zildenilson da Silva Sousa, Thales Peres Candido Moreira, Perilo Marques Chaves Júnior, Ana Carolina da Silva Matias, Valéria Pinto dos Santos, Moysés Matias Mateus, Débora Landim Marques, Samara Evangelista da Silva, José Rafael de Sá Alves, Bruna Damasceno Sá, Michelle Carregosa Andrade https://creativecommons.org/licenses/by/4.0

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