PREOPERATIVE HALP SCORE AS A PREDICTOR OF SURVIVAL IN LOCALLY ADVANCED COLON CANCER: Colon cancer and HALP score

Introduction: Lower preoperative hemoglobin (H), albumin (A), lymphocyte (L) and platelet (P) score (HALP) has been identified as a predictive factor in LACC to categorize patients with higher risk of poor outcome. Therefore, it is important to identify biomarkers available in clinical practice that...

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Principais autores: Amado, Andreia, Pimenta, Joana, Queirós, Tatiana, Leite, Mariana, Tavares, Amélia, Cardoso, João, Gandra, Lurdes, Oliveira, Manuel
Formato: Online
Idioma:eng
Publicado em: FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
Endereço do item:https://periodicos.ufrn.br/jscr/article/view/29546
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spelling oai:periodicos.ufrn.br:article-295462022-10-08T16:14:02Z PREOPERATIVE HALP SCORE AS A PREDICTOR OF SURVIVAL IN LOCALLY ADVANCED COLON CANCER: Colon cancer and HALP score Amado, Andreia Pimenta, Joana Queirós, Tatiana Leite, Mariana Tavares, Amélia Cardoso, João Gandra, Lurdes Oliveira, Manuel Colon biomarker halp score colon cancer Introduction: Lower preoperative hemoglobin (H), albumin (A), lymphocyte (L) and platelet (P) score (HALP) has been identified as a predictive factor in LACC to categorize patients with higher risk of poor outcome. Therefore, it is important to identify biomarkers available in clinical practice that can predict survival and patient’s prognosis. Our aim is to evaluate preoperative HALP score and its prognostic value.   Materials and Methods: Our retrospective study included patients with LACC submitted to oncologic resection between January 2015 to December 2019 in our institution. LACC included stages II and III adenocarcinoma. HALP score was calculated as H (g/L) x A (g/L) x L (/L) / P (/L). A cutoff value was determined by ROC curve analysis and patients were divided accordingly into two groups (low and high HALP) to compare cancer-specific survival, through Kaplan-Meyer curve.   Results: In our study, 127 patients were included. The mean age was 70,7 ± 11,9 years and 67 (52,8%) were male. Stage II incorporated 65 patients (51,2%) and stage III 62 (48,8%). The median follow-up time was 37 months. The HALP cutoff value estimated was 22,5. Age ³ 65 years, right-sided tumor, surgical reintervention and cancer-specific survival were associated with a lower HALP scores (p=0,002; p=0,004; p=0,008 and p=0.001, respectively).     Conclusion: Nutritional and systemic inflammation status are extremely important in colon cancer prognosis. Serum biomarkers, such as HALP score could easily identify patients with a higher risk of poor outcome. Thus, this prognostic index may be useful as a clinical predictor of survival for LACC patients. FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL 2022-10-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://periodicos.ufrn.br/jscr/article/view/29546 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; Vol. 13 No. 1 (2022); 1-9 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; v. 13 n. 1 (2022); 1-9 2179-7889 eng https://periodicos.ufrn.br/jscr/article/view/29546/16168 Copyright (c) 2022 JOURNAL OF SURGICAL AND CLINICAL RESEARCH http://creativecommons.org/licenses/by-nc-sa/4.0
institution Periódicos UFRN
collection Portal de Pediódicos Eletrônicos da UFRN
language eng
format Online
author Amado, Andreia
Pimenta, Joana
Queirós, Tatiana
Leite, Mariana
Tavares, Amélia
Cardoso, João
Gandra, Lurdes
Oliveira, Manuel
spellingShingle Amado, Andreia
Pimenta, Joana
Queirós, Tatiana
Leite, Mariana
Tavares, Amélia
Cardoso, João
Gandra, Lurdes
Oliveira, Manuel
PREOPERATIVE HALP SCORE AS A PREDICTOR OF SURVIVAL IN LOCALLY ADVANCED COLON CANCER: Colon cancer and HALP score
author_facet Amado, Andreia
Pimenta, Joana
Queirós, Tatiana
Leite, Mariana
Tavares, Amélia
Cardoso, João
Gandra, Lurdes
Oliveira, Manuel
author_sort Amado, Andreia
title PREOPERATIVE HALP SCORE AS A PREDICTOR OF SURVIVAL IN LOCALLY ADVANCED COLON CANCER: Colon cancer and HALP score
title_short PREOPERATIVE HALP SCORE AS A PREDICTOR OF SURVIVAL IN LOCALLY ADVANCED COLON CANCER: Colon cancer and HALP score
title_full PREOPERATIVE HALP SCORE AS A PREDICTOR OF SURVIVAL IN LOCALLY ADVANCED COLON CANCER: Colon cancer and HALP score
title_fullStr PREOPERATIVE HALP SCORE AS A PREDICTOR OF SURVIVAL IN LOCALLY ADVANCED COLON CANCER: Colon cancer and HALP score
title_full_unstemmed PREOPERATIVE HALP SCORE AS A PREDICTOR OF SURVIVAL IN LOCALLY ADVANCED COLON CANCER: Colon cancer and HALP score
title_sort preoperative halp score as a predictor of survival in locally advanced colon cancer: colon cancer and halp score
description Introduction: Lower preoperative hemoglobin (H), albumin (A), lymphocyte (L) and platelet (P) score (HALP) has been identified as a predictive factor in LACC to categorize patients with higher risk of poor outcome. Therefore, it is important to identify biomarkers available in clinical practice that can predict survival and patient’s prognosis. Our aim is to evaluate preoperative HALP score and its prognostic value.   Materials and Methods: Our retrospective study included patients with LACC submitted to oncologic resection between January 2015 to December 2019 in our institution. LACC included stages II and III adenocarcinoma. HALP score was calculated as H (g/L) x A (g/L) x L (/L) / P (/L). A cutoff value was determined by ROC curve analysis and patients were divided accordingly into two groups (low and high HALP) to compare cancer-specific survival, through Kaplan-Meyer curve.   Results: In our study, 127 patients were included. The mean age was 70,7 ± 11,9 years and 67 (52,8%) were male. Stage II incorporated 65 patients (51,2%) and stage III 62 (48,8%). The median follow-up time was 37 months. The HALP cutoff value estimated was 22,5. Age ³ 65 years, right-sided tumor, surgical reintervention and cancer-specific survival were associated with a lower HALP scores (p=0,002; p=0,004; p=0,008 and p=0.001, respectively).     Conclusion: Nutritional and systemic inflammation status are extremely important in colon cancer prognosis. Serum biomarkers, such as HALP score could easily identify patients with a higher risk of poor outcome. Thus, this prognostic index may be useful as a clinical predictor of survival for LACC patients.
publisher FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
publishDate 2022
url https://periodicos.ufrn.br/jscr/article/view/29546
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