Mandibular necrosis associated with biphosphonate use: case report

Introduction: Bisphosphonates are drugs that aim to reduce bone resorption by causing apoptosis of osteoclasts. For this reason, they are often used in patients with osteoporosis and in the treatment of cancer. However, despite the benefits associated with treatment with bisphosphonates, these medic...

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Principais autores: Freitas de Souza Junior, Erasmo, Azevedo Silva, Janielma, do Socorro Soares, Maria, Henrique Araújo de Morais, Hécio
Formato: Online
Idioma:por
Publicado em: Portal de Periódicos Eletrônicos da UFRN
Endereço do item:https://periodicos.ufrn.br/rcp/article/view/19671
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record_format ojs
institution Periódicos UFRN
collection Portal de Pediódicos Eletrônicos da UFRN
language por
format Online
author Freitas de Souza Junior, Erasmo
Azevedo Silva, Janielma
do Socorro Soares, Maria
Henrique Araújo de Morais, Hécio
spellingShingle Freitas de Souza Junior, Erasmo
Azevedo Silva, Janielma
do Socorro Soares, Maria
Henrique Araújo de Morais, Hécio
Mandibular necrosis associated with biphosphonate use: case report
author_facet Freitas de Souza Junior, Erasmo
Azevedo Silva, Janielma
do Socorro Soares, Maria
Henrique Araújo de Morais, Hécio
author_sort Freitas de Souza Junior, Erasmo
title Mandibular necrosis associated with biphosphonate use: case report
title_short Mandibular necrosis associated with biphosphonate use: case report
title_full Mandibular necrosis associated with biphosphonate use: case report
title_fullStr Mandibular necrosis associated with biphosphonate use: case report
title_full_unstemmed Mandibular necrosis associated with biphosphonate use: case report
title_sort mandibular necrosis associated with biphosphonate use: case report
description Introduction: Bisphosphonates are drugs that aim to reduce bone resorption by causing apoptosis of osteoclasts. For this reason, they are often used in patients with osteoporosis and in the treatment of cancer. However, despite the benefits associated with treatment with bisphosphonates, these medications have been related to maxillo-mandibular osteonecrosis, materializing as a worrying scenario of interest to public health. Objective: Present a clinical case of mandibular osteonecrosis associated with the use of bifosfanate, after extraction of a dental element, as well as to contribute with the discussions about the therapeutic possibilities of this disease. Case description: A 59-year-old male patient was referred to the Buccomaxillofacial Surgery and Traumatology department two months after dental extraction of the element 45. The diagnosis was bisphosphonate-related maxillomandibular osteonecrosis (OMRB), initially opting removal of existing trauma, as well as care for the exposed area. Subsequently, we chose to remove the necrotic bone segment. Conclusions: The complex pathophysiology of OMRB requires dental surgeons to take measures in a timely manner and cause minimal disruption to patients' lives. Thus, the state of the lesion should be evaluated, with conservative therapy indicated for early findings. Surgical debridement is advised for the treatment of advanced and unresponsive disease. Keywords: Bisphosphonates; Osteonecrosis; Jaw.
publisher Portal de Periódicos Eletrônicos da UFRN
publishDate 2020
url https://periodicos.ufrn.br/rcp/article/view/19671
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spelling oai:periodicos.ufrn.br:article-196712020-07-10T22:27:23Z Mandibular necrosis associated with biphosphonate use: case report Necrosis mandibular asociada al uso de bifosfonato: relato de caso NECROSE MANDIBULAR ASSOCIADA AO USO DE BIFOSFONATO: RELATO DE CASO Freitas de Souza Junior, Erasmo Azevedo Silva, Janielma do Socorro Soares, Maria Henrique Araújo de Morais, Hécio Introduction: Bisphosphonates are drugs that aim to reduce bone resorption by causing apoptosis of osteoclasts. For this reason, they are often used in patients with osteoporosis and in the treatment of cancer. However, despite the benefits associated with treatment with bisphosphonates, these medications have been related to maxillo-mandibular osteonecrosis, materializing as a worrying scenario of interest to public health. Objective: Present a clinical case of mandibular osteonecrosis associated with the use of bifosfanate, after extraction of a dental element, as well as to contribute with the discussions about the therapeutic possibilities of this disease. Case description: A 59-year-old male patient was referred to the Buccomaxillofacial Surgery and Traumatology department two months after dental extraction of the element 45. The diagnosis was bisphosphonate-related maxillomandibular osteonecrosis (OMRB), initially opting removal of existing trauma, as well as care for the exposed area. Subsequently, we chose to remove the necrotic bone segment. Conclusions: The complex pathophysiology of OMRB requires dental surgeons to take measures in a timely manner and cause minimal disruption to patients' lives. Thus, the state of the lesion should be evaluated, with conservative therapy indicated for early findings. Surgical debridement is advised for the treatment of advanced and unresponsive disease. Keywords: Bisphosphonates; Osteonecrosis; Jaw. Introducción: Los bisfosfonatos son medicamentos que tienen como objetivo reducir la resorción ósea al causar apoptosis de osteoclastos. Por esta razón, a menudo se usan en pacientes con osteoporosis y en el tratamiento del cáncer. Sin embargo, a pesar de los beneficios asociados con el tratamiento con bisfosfonatos, estos medicamentos se han relacionado con la osteonecrosis maxilomandibular, materializándose como un escenario preocupante de interés para la salud pública. Objetivo: Presentar un caso clínico de osteonecrosis mandibular asociada con el uso de bisfosfanato después de la extracción de un elemento dental, así como contribuir a las discusiones sobre las posibilidades terapéuticas de esta enfermedad. Descripción del caso: un paciente masculino de 59 años fue derivado del Departamento de Traumatología y Cirugía Buccomaxilofacial después de meses de extracción dental 45. El diagnóstico era de osteonecrosis maxilomandibular relacionada con bifosfonatos (OMRB), inicialmente eligiendo  eliminar los traumas existente, bien como del cuidado con el área expuesta. Posteriormente, elegimos eliminar el segmento óseo necrótico. Conclusiones: La compleja fisiopatología de la OMRB requiere de cirujanos  dentista para tomar medidas de manera oportuna y causar el menor inconveniente la vida de pacientes al mínimo. Por lo tanto, se debe evaluar el estado de la lesión, con terapia conservadora indicada para hallazgos tempranos. Se recomienda el desbridamiento quirúrgico para el tratamiento de enfermedades avanzadas y que no responden. Palabras clave: Bisfosfonatos; Osteonecrosis; Mandíbula. Introdução: Os bifosfonatos são medicamentos que objetivam reduzir a reabsorção óssea por provocarem a apoptose de osteoclastos. Por essa razão, são frequentemente empregados em pacientes com osteoporose e no tratamento do câncer. Contudo, apesar dos benefícios associados ao tratamento com bifosfonatos, esses medicamentos vêm sendo relacionados a osteonecrose maxilo-mandibular, materializando-se como um preocupante quadro de interesse à saúde pública. Objetivo: Apresentar um caso clínico de osteonecrose mandibular associada ao uso de bifosfanato, após extração de um elemento dentário, bem como contribuir com as discussões sobre as possibilidades terapêuticas desta enfermidade. Descrição do caso: Paciente do sexo masculino, 59 anos, encaminhado ao serviço de Cirurgia e Traumatologia Bucomaxilofacial dois meses após a extração do elemento dentário 45. O diagnóstico foi de Osteonecrose Maxilomandibular Relacionada a Bifosfonatos (OMRB), optando-se, inicialmente, pela remoção dos traumas existentes, como também o cuidado com a área exposta. Posteriormente, optou-se pela remoção do segmento ósseo necrótico. Conclusões: A complexa fisiopatologia da OMRB, exige dos cirurgiões dentistas a tomada de medidas em tempo oportuno e que cause o mínimo transtorno à vida dos pacientes. Assim, deve-se avaliar o estado da lesão, havendo indicação de terapia conservadora para os achados precoces. O desbridamento cirúrgico é aconselhado para o tratamento da doença avançada e não responsiva. Palavras-Chave: Bifosfonatos; Osteonecrose; Mandíbula. Portal de Periódicos Eletrônicos da UFRN 2020-06-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://periodicos.ufrn.br/rcp/article/view/19671 Revista Ciência Plural; v. 6 n. 2 (2020): Revista Ciência Plural; 205-219 2446-7286 10.21680/2446-7286.2020v6n2 por https://periodicos.ufrn.br/rcp/article/view/19671/12852 Copyright (c) 2020 Revista Ciência Plural

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