Levamisole in treatment of urethane-induced pulmonary carcinoma in rats

Objective: The potential antitumor effects of the levamisole immunomodulatory agent remain uncertain, and its beneficial effects with increased survival in the adjuvant treatment of malignant tumors are controversial. The present study aims to compare the effects of levamisole with cisplatin in the...

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Principais autores: Luiz Costa e Silva, André, Medeiros Soares Celani, Livia, Medeiros Azevedo, Italo, Cunha Medeiros, Aldo
Formato: Online
Idioma:eng
Publicado em: FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
Endereço do item:https://periodicos.ufrn.br/jscr/article/view/18782
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spelling oai:periodicos.ufrn.br:article-187822019-10-11T19:55:55Z Levamisole in treatment of urethane-induced pulmonary carcinoma in rats Luiz Costa e Silva, André Medeiros Soares Celani, Livia Medeiros Azevedo, Italo Cunha Medeiros, Aldo Lung carcinoma. Carcinogenesis. Urethane. Treatment. Levamisole. Cisplatin. Rats Objective: The potential antitumor effects of the levamisole immunomodulatory agent remain uncertain, and its beneficial effects with increased survival in the adjuvant treatment of malignant tumors are controversial. The present study aims to compare the effects of levamisole with cisplatin in the treatment of urethane-induced lung carcinoma in rats. Methods: Wistar rats were allocated into three groups (n = six each). Group A: mice with lung tumor + treatment with levamisole. Group B: mice with lung tumor + cisplatin treatment. Group C: mice with lung tumor + saline treatment. After 12 weeks of the tumor induction process, the results were validated by ex vivo fluorescence imaging, determining the mean fluorescent intensity in the animal’s lungs. Serum dosages of cytokines and alkaline phosphatase were performed. Results: Mean fluorescence intensity (MFI) in the lungs (ex vivo) was measured in all animals subjected to urethane effects. In levamisole-treated, the intensity (245 +/- 15) was lower than in cisplatin-treated (277 +/- 28), but the difference was not statistically significant (p<0.05). In those treated with saline, the MFI was 680 +/- 57, significantly higher than in the other groups (p<0.05). Dosages of TNF-? (pg/ml), IL-I? (pg/ml), IL-6 (pg/ml) and alkaline phosphatase (mg/dl) were significantly lower in levamisole-treated rats than in rats with cisplatin and saline (p<0.005). Conclusion: In conclusion, this study demonstrates the positive influence of levamisole in treatment of urethane-induced lung tumors in rats. FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL 2019-10-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://periodicos.ufrn.br/jscr/article/view/18782 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; Vol. 10 No. 2 (2019); 54-64 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; v. 10 n. 2 (2019); 54-64 2179-7889 eng https://periodicos.ufrn.br/jscr/article/view/18782/12141 Copyright (c) 2019 JOURNAL OF SURGICAL AND CLINICAL RESEARCH
institution Periódicos UFRN
collection Portal de Pediódicos Eletrônicos da UFRN
language eng
format Online
author Luiz Costa e Silva, André
Medeiros Soares Celani, Livia
Medeiros Azevedo, Italo
Cunha Medeiros, Aldo
spellingShingle Luiz Costa e Silva, André
Medeiros Soares Celani, Livia
Medeiros Azevedo, Italo
Cunha Medeiros, Aldo
Levamisole in treatment of urethane-induced pulmonary carcinoma in rats
author_facet Luiz Costa e Silva, André
Medeiros Soares Celani, Livia
Medeiros Azevedo, Italo
Cunha Medeiros, Aldo
author_sort Luiz Costa e Silva, André
title Levamisole in treatment of urethane-induced pulmonary carcinoma in rats
title_short Levamisole in treatment of urethane-induced pulmonary carcinoma in rats
title_full Levamisole in treatment of urethane-induced pulmonary carcinoma in rats
title_fullStr Levamisole in treatment of urethane-induced pulmonary carcinoma in rats
title_full_unstemmed Levamisole in treatment of urethane-induced pulmonary carcinoma in rats
title_sort levamisole in treatment of urethane-induced pulmonary carcinoma in rats
description Objective: The potential antitumor effects of the levamisole immunomodulatory agent remain uncertain, and its beneficial effects with increased survival in the adjuvant treatment of malignant tumors are controversial. The present study aims to compare the effects of levamisole with cisplatin in the treatment of urethane-induced lung carcinoma in rats. Methods: Wistar rats were allocated into three groups (n = six each). Group A: mice with lung tumor + treatment with levamisole. Group B: mice with lung tumor + cisplatin treatment. Group C: mice with lung tumor + saline treatment. After 12 weeks of the tumor induction process, the results were validated by ex vivo fluorescence imaging, determining the mean fluorescent intensity in the animal’s lungs. Serum dosages of cytokines and alkaline phosphatase were performed. Results: Mean fluorescence intensity (MFI) in the lungs (ex vivo) was measured in all animals subjected to urethane effects. In levamisole-treated, the intensity (245 +/- 15) was lower than in cisplatin-treated (277 +/- 28), but the difference was not statistically significant (p<0.05). In those treated with saline, the MFI was 680 +/- 57, significantly higher than in the other groups (p<0.05). Dosages of TNF-? (pg/ml), IL-I? (pg/ml), IL-6 (pg/ml) and alkaline phosphatase (mg/dl) were significantly lower in levamisole-treated rats than in rats with cisplatin and saline (p<0.005). Conclusion: In conclusion, this study demonstrates the positive influence of levamisole in treatment of urethane-induced lung tumors in rats.
publisher FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
publishDate 2019
url https://periodicos.ufrn.br/jscr/article/view/18782
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AT medeirossoarescelanilivia levamisoleintreatmentofurethaneinducedpulmonarycarcinomainrats
AT medeirosazevedoitalo levamisoleintreatmentofurethaneinducedpulmonarycarcinomainrats
AT cunhamedeirosaldo levamisoleintreatmentofurethaneinducedpulmonarycarcinomainrats
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