Effect of Ringer's solution submitted to magnetic field in renal ischemia-reperfusion model in rats

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Purpose: To evaluate the effect of hydration with simple Ringer's solution submitted to magnetic field in rats under renal ischemia and reperfusion (I/R) model, using biochemical and histopathological evaluation. Methods: Wistar rats were allocated into 2 equal groups of 6 animals each: Renal i...

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Principais autores: Souza, Jeovana Pinheiro Fernandes de, Freire, Juliana Mendonça, Azevedo, Italo Medeiros, Azevedo, Fabio Medeiros de, Carriço, Artur da Silva, Medeiros, Aldo Cunha
Formato: Online
Idioma:eng
Publicado em: FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
Endereço do item:https://periodicos.ufrn.br/jscr/article/view/15915
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spelling oai:periodicos.ufrn.br:article-159152018-11-09T17:16:44Z Effect of Ringer's solution submitted to magnetic field in renal ischemia-reperfusion model in rats Souza, Jeovana Pinheiro Fernandes de Freire, Juliana Mendonça Azevedo, Italo Medeiros Azevedo, Fabio Medeiros de Carriço, Artur da Silva Medeiros, Aldo Cunha Purpose: To evaluate the effect of hydration with simple Ringer's solution submitted to magnetic field in rats under renal ischemia and reperfusion (I/R) model, using biochemical and histopathological evaluation. Methods: Wistar rats were allocated into 2 equal groups of 6 animals each: Renal ischemia/reperfusion group + hydration with magnetic Ringer (mag Ringer).  The left kidney underwent ischemia for 30 minutes. The right kidney was not manipulated. Thereafter, i.v. hydration was performed with 3 ml mag Ringer; Group renal I/R + hidration with simple Ringer. The simple Ringer solution was submitted to a magnetic field of 20mT intensity for 2 hours immediately prior to the surgical procedure. After 24 hours, under anesthesia blood was collected for dosing serum urea and creatinine. Histopathological analysis was performed on the left kidney (HE staining). Results: There was no significant difference between the creatinine (p=0.764) and urea (p = 0.926) values ??between the control and test groups (non-parametric Mann-Whitney test). Comparing the histopathological scores, there was a significant difference between the groups, with higher levels of lesions in the mag Ringer treated group (p=0.025) - Mann-Whitney test. Conclusion: The use of Ringer's solution submitted to magnetic field for intravenous hydration in a renal ischemia/reperfusion model did not alter the renal function and had a negative influence on the histopathological findings on the kidney, when compared to control. FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL 2018-11-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://periodicos.ufrn.br/jscr/article/view/15915 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; Vol. 9 No. 2 (2018); 33-43 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; v. 9 n. 2 (2018); 33-43 2179-7889 eng https://periodicos.ufrn.br/jscr/article/view/15915/10761
institution Periódicos UFRN
collection Portal de Pediódicos Eletrônicos da UFRN
language eng
format Online
author Souza, Jeovana Pinheiro Fernandes de
Freire, Juliana Mendonça
Azevedo, Italo Medeiros
Azevedo, Fabio Medeiros de
Carriço, Artur da Silva
Medeiros, Aldo Cunha
spellingShingle Souza, Jeovana Pinheiro Fernandes de
Freire, Juliana Mendonça
Azevedo, Italo Medeiros
Azevedo, Fabio Medeiros de
Carriço, Artur da Silva
Medeiros, Aldo Cunha
Effect of Ringer's solution submitted to magnetic field in renal ischemia-reperfusion model in rats
author_facet Souza, Jeovana Pinheiro Fernandes de
Freire, Juliana Mendonça
Azevedo, Italo Medeiros
Azevedo, Fabio Medeiros de
Carriço, Artur da Silva
Medeiros, Aldo Cunha
author_sort Souza, Jeovana Pinheiro Fernandes de
title Effect of Ringer's solution submitted to magnetic field in renal ischemia-reperfusion model in rats
title_short Effect of Ringer's solution submitted to magnetic field in renal ischemia-reperfusion model in rats
title_full Effect of Ringer's solution submitted to magnetic field in renal ischemia-reperfusion model in rats
title_fullStr Effect of Ringer's solution submitted to magnetic field in renal ischemia-reperfusion model in rats
title_full_unstemmed Effect of Ringer's solution submitted to magnetic field in renal ischemia-reperfusion model in rats
title_sort effect of ringer's solution submitted to magnetic field in renal ischemia-reperfusion model in rats
description Purpose: To evaluate the effect of hydration with simple Ringer's solution submitted to magnetic field in rats under renal ischemia and reperfusion (I/R) model, using biochemical and histopathological evaluation. Methods: Wistar rats were allocated into 2 equal groups of 6 animals each: Renal ischemia/reperfusion group + hydration with magnetic Ringer (mag Ringer).  The left kidney underwent ischemia for 30 minutes. The right kidney was not manipulated. Thereafter, i.v. hydration was performed with 3 ml mag Ringer; Group renal I/R + hidration with simple Ringer. The simple Ringer solution was submitted to a magnetic field of 20mT intensity for 2 hours immediately prior to the surgical procedure. After 24 hours, under anesthesia blood was collected for dosing serum urea and creatinine. Histopathological analysis was performed on the left kidney (HE staining). Results: There was no significant difference between the creatinine (p=0.764) and urea (p = 0.926) values ??between the control and test groups (non-parametric Mann-Whitney test). Comparing the histopathological scores, there was a significant difference between the groups, with higher levels of lesions in the mag Ringer treated group (p=0.025) - Mann-Whitney test. Conclusion: The use of Ringer's solution submitted to magnetic field for intravenous hydration in a renal ischemia/reperfusion model did not alter the renal function and had a negative influence on the histopathological findings on the kidney, when compared to control.
publisher FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
publishDate 2018
url https://periodicos.ufrn.br/jscr/article/view/15915
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