Use of simvastatin in the prevention of cyclophosphamide-induced ureteral mucositis

Purpose: This study was designed to investigate the pharmacological efficacy of simvastatin against ureteral mucositis cyclophosphamide-induced. Methods: Wistar rats weighing 287±14g were used. A single dose of cyclophosphamide (CYP) 200mg/kg IP + oral simvastatin (10mg/kg) were administered in the...

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Principais autores: Maia, Beatriz Stephanie da Silva, Celani, Lívia Medeiros Soares, Moreira, Marília Daniela Ferreira de Carvalho, Araújo-Filho, Irami, Medeiros, Aldo Cunha
Formato: Online
Idioma:por
Publicado em: FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
Endereço do item:https://periodicos.ufrn.br/jscr/article/view/14302
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spelling oai:periodicos.ufrn.br:article-143022019-06-05T23:30:56Z Use of simvastatin in the prevention of cyclophosphamide-induced ureteral mucositis Maia, Beatriz Stephanie da Silva Celani, Lívia Medeiros Soares Moreira, Marília Daniela Ferreira de Carvalho Araújo-Filho, Irami Medeiros, Aldo Cunha Ureter. Mucositis. Cyclophosphamide. Simvastatin. Treatment. Rats Purpose: This study was designed to investigate the pharmacological efficacy of simvastatin against ureteral mucositis cyclophosphamide-induced. Methods: Wistar rats weighing 287±14g were used. A single dose of cyclophosphamide (CYP) 200mg/kg IP + oral simvastatin (10mg/kg) were administered in the (CYP/SIMV)  group (n=6), In the group (CYP/SAL) (n=6), saline v.o. was administered. The animals were weighed daily. After 7 days of CYP administration, blood was collected by cardiac puncture under anesthesia. After euthanasia, uterers were collected for histopathology. Serum TNF-?, IL-1?, IL-6 were determined by ELISA.  Results: CYP-induced ureteral mucositis in rats resulted in a significant increased level of serum cytokines (TNF-?, IL-1b, IL-6). Simvastatin treated rats showed significant decreased level of inflammatory cytokines. In body weight records, CYP-treated rats showed visible significant body mass loss compared to untreated rats (p<0.05). Edema and inflammatory cells in ureter tissues were reduced after simvastatin treatment, as demonstrated in histological H-E staining. Conclusion: In conclusion, our current findings provided scientific evidence that oral simvastatin positively influenced benefits against cyclophosphamide-induced ureter mucositis, which possibly has occurred by inactivating cytokines. FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL 2018-05-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://periodicos.ufrn.br/jscr/article/view/14302 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; Vol. 8 No. 2 (2017); 130-139 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; v. 8 n. 2 (2017); 130-139 2179-7889 por https://periodicos.ufrn.br/jscr/article/view/14302/9448 Copyright (c) 2018 JOURNAL OF SURGICAL AND CLINICAL RESEARCH
institution Periódicos UFRN
collection Portal de Pediódicos Eletrônicos da UFRN
language por
format Online
author Maia, Beatriz Stephanie da Silva
Celani, Lívia Medeiros Soares
Moreira, Marília Daniela Ferreira de Carvalho
Araújo-Filho, Irami
Medeiros, Aldo Cunha
spellingShingle Maia, Beatriz Stephanie da Silva
Celani, Lívia Medeiros Soares
Moreira, Marília Daniela Ferreira de Carvalho
Araújo-Filho, Irami
Medeiros, Aldo Cunha
Use of simvastatin in the prevention of cyclophosphamide-induced ureteral mucositis
author_facet Maia, Beatriz Stephanie da Silva
Celani, Lívia Medeiros Soares
Moreira, Marília Daniela Ferreira de Carvalho
Araújo-Filho, Irami
Medeiros, Aldo Cunha
author_sort Maia, Beatriz Stephanie da Silva
title Use of simvastatin in the prevention of cyclophosphamide-induced ureteral mucositis
title_short Use of simvastatin in the prevention of cyclophosphamide-induced ureteral mucositis
title_full Use of simvastatin in the prevention of cyclophosphamide-induced ureteral mucositis
title_fullStr Use of simvastatin in the prevention of cyclophosphamide-induced ureteral mucositis
title_full_unstemmed Use of simvastatin in the prevention of cyclophosphamide-induced ureteral mucositis
title_sort use of simvastatin in the prevention of cyclophosphamide-induced ureteral mucositis
description Purpose: This study was designed to investigate the pharmacological efficacy of simvastatin against ureteral mucositis cyclophosphamide-induced. Methods: Wistar rats weighing 287±14g were used. A single dose of cyclophosphamide (CYP) 200mg/kg IP + oral simvastatin (10mg/kg) were administered in the (CYP/SIMV)  group (n=6), In the group (CYP/SAL) (n=6), saline v.o. was administered. The animals were weighed daily. After 7 days of CYP administration, blood was collected by cardiac puncture under anesthesia. After euthanasia, uterers were collected for histopathology. Serum TNF-?, IL-1?, IL-6 were determined by ELISA.  Results: CYP-induced ureteral mucositis in rats resulted in a significant increased level of serum cytokines (TNF-?, IL-1b, IL-6). Simvastatin treated rats showed significant decreased level of inflammatory cytokines. In body weight records, CYP-treated rats showed visible significant body mass loss compared to untreated rats (p<0.05). Edema and inflammatory cells in ureter tissues were reduced after simvastatin treatment, as demonstrated in histological H-E staining. Conclusion: In conclusion, our current findings provided scientific evidence that oral simvastatin positively influenced benefits against cyclophosphamide-induced ureter mucositis, which possibly has occurred by inactivating cytokines.
publisher FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
publishDate 2018
url https://periodicos.ufrn.br/jscr/article/view/14302
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