Predictors of Malignancy in Patients With Thyroid Nodule(s)

Purpose: To detect the predictors of malignancy in patients with thyroid nodule(s). Background: Thyroid nodules are common surgical problem with 5-10% risk of malignancy. Thyroid surgery is a major operation with many complications. So, it is important to search for the predictors of malignancy in t...

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Principais autores: Alatiar, Islam, Elfol, Hassam, Rageh, Tarek
Formato: Online
Idioma:por
Publicado em: FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
Endereço do item:https://periodicos.ufrn.br/jscr/article/view/13031
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spelling oai:periodicos.ufrn.br:article-130312017-11-03T17:05:52Z Predictors of Malignancy in Patients With Thyroid Nodule(s) Alatiar, Islam Elfol, Hassam Rageh, Tarek Goiter nodular. Malignancy. Multinodular goiter. Nodules solitary. Ultrasound Purpose: To detect the predictors of malignancy in patients with thyroid nodule(s). Background: Thyroid nodules are common surgical problem with 5-10% risk of malignancy. Thyroid surgery is a major operation with many complications. So, it is important to search for the predictors of malignancy in thyroid nodules to spare more benign lesions from surgery. Patients and methods: This prospective study includes 150 patients with thyroid nodule(s), all were admitted for thyroidectomy at Menoufia University Hospital. Demographic and clinical data, ultrasound, fine needle aspiration reports and final histopathology were recorded and analyzed. Patients with previous thyroid surgery or previous neck biopsy were excluded. Results: About 20% of the studied population proved to have malignant nodules on final histopathology reports. Out of 150 cases, there were 83 with multi-nodular goiter and 67 with solitary thyroid nodules. There were higher incidence of malignancy in male patients. The incidence also was higher in solitary nodules than in multinodular goiter. There were statistically significant ultrasound features differences such as; micro-calcifications, ill-defined edges, solid consistency, hypo-echoic pattern, intra-nodular vascularity and size below 2cm. Regarding fine needle biopsy, there were a significant increase in incidence of malignancy from Bethesda(II) – Bethesda(VI) with highest incidence in Bethesda(VI). Conclusion: Predictors of malignancy detected were; male gender, solitary nodules, micro-calcifications, hypo-echoic pattern, ill-defined edges, intra-nodular vascularity, solid nodules, size below 2 cm and Bethesda VI. Large scale multi center studies are needed for more solid statistical result. FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL 2017-11-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://periodicos.ufrn.br/jscr/article/view/13031 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; Vol. 8 No. 1 (2017); 1-13 JOURNAL OF SURGICAL AND CLINICAL RESEARCH; v. 8 n. 1 (2017); 1-13 2179-7889 por https://periodicos.ufrn.br/jscr/article/view/13031/8919 Copyright (c) 2017 JOURNAL OF SURGICAL AND CLINICAL RESEARCH
institution Periódicos UFRN
collection Portal de Pediódicos Eletrônicos da UFRN
language por
format Online
author Alatiar, Islam
Elfol, Hassam
Rageh, Tarek
spellingShingle Alatiar, Islam
Elfol, Hassam
Rageh, Tarek
Predictors of Malignancy in Patients With Thyroid Nodule(s)
author_facet Alatiar, Islam
Elfol, Hassam
Rageh, Tarek
author_sort Alatiar, Islam
title Predictors of Malignancy in Patients With Thyroid Nodule(s)
title_short Predictors of Malignancy in Patients With Thyroid Nodule(s)
title_full Predictors of Malignancy in Patients With Thyroid Nodule(s)
title_fullStr Predictors of Malignancy in Patients With Thyroid Nodule(s)
title_full_unstemmed Predictors of Malignancy in Patients With Thyroid Nodule(s)
title_sort predictors of malignancy in patients with thyroid nodule(s)
description Purpose: To detect the predictors of malignancy in patients with thyroid nodule(s). Background: Thyroid nodules are common surgical problem with 5-10% risk of malignancy. Thyroid surgery is a major operation with many complications. So, it is important to search for the predictors of malignancy in thyroid nodules to spare more benign lesions from surgery. Patients and methods: This prospective study includes 150 patients with thyroid nodule(s), all were admitted for thyroidectomy at Menoufia University Hospital. Demographic and clinical data, ultrasound, fine needle aspiration reports and final histopathology were recorded and analyzed. Patients with previous thyroid surgery or previous neck biopsy were excluded. Results: About 20% of the studied population proved to have malignant nodules on final histopathology reports. Out of 150 cases, there were 83 with multi-nodular goiter and 67 with solitary thyroid nodules. There were higher incidence of malignancy in male patients. The incidence also was higher in solitary nodules than in multinodular goiter. There were statistically significant ultrasound features differences such as; micro-calcifications, ill-defined edges, solid consistency, hypo-echoic pattern, intra-nodular vascularity and size below 2cm. Regarding fine needle biopsy, there were a significant increase in incidence of malignancy from Bethesda(II) – Bethesda(VI) with highest incidence in Bethesda(VI). Conclusion: Predictors of malignancy detected were; male gender, solitary nodules, micro-calcifications, hypo-echoic pattern, ill-defined edges, intra-nodular vascularity, solid nodules, size below 2 cm and Bethesda VI. Large scale multi center studies are needed for more solid statistical result.
publisher FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE, BRAZIL
publishDate 2017
url https://periodicos.ufrn.br/jscr/article/view/13031
work_keys_str_mv AT alatiarislam predictorsofmalignancyinpatientswiththyroidnodules
AT elfolhassam predictorsofmalignancyinpatientswiththyroidnodules
AT ragehtarek predictorsofmalignancyinpatientswiththyroidnodules
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