The Immune Synapse as a Novel Target for Therapy

The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell APC junction. It plays an essential role in the control and nature...

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Principais autores: Graca, Luis., SpringerLink (Online service)
Formato: Digital
Publicado em:
Assuntos:
Imunologia.
Alergia.
Toxicologia.
Citologia.
Biomedicina.
Endereço do item:http://dx.doi.org/10.1007/978-3-7643-8296-4
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spelling oai:localhost:123456789-2125962023-07-17T15:09:21Z The Immune Synapse as a Novel Target for Therapy Graca, Luis. SpringerLink (Online service) Imunologia. Alergia. Toxicologia. Citologia. Biomedicina. The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell APC junction. It plays an essential role in the control and nature of the immune response. In recent years several approaches have been developed to reprogram the immune response by targeting molecules involved in the immune synapse. Monoclonal antibodies, such as those targeting the lymphocyte co-receptor, costimulatory and adhesion molecules (CD3, CD4, CD40L, CTLA4-Ig, LFA-1), or altered peptide ligands have been shown capable of inducing immune tolerance in transplantation, autoimmunity and allergy. This volume discusses the progress in the field, from basic science to clinical trials, and the major mechanisms involved. It is of interest to clinicians and researchers working in this area. 0 2022-10-11T17:43:03Z 2022-10-11T17:43:03Z 2008. Digital 616-097 I33 9783764382964 198684 http://dx.doi.org/10.1007/978-3-7643-8296-4 http://dx.doi.org/10.1007/978-3-7643-8296-4
institution Acervo SISBI
collection SIGAA
topic Imunologia.
Alergia.
Toxicologia.
Citologia.
Biomedicina.
spellingShingle Imunologia.
Alergia.
Toxicologia.
Citologia.
Biomedicina.
Graca, Luis.
SpringerLink (Online service)
The Immune Synapse as a Novel Target for Therapy
description The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell APC junction. It plays an essential role in the control and nature of the immune response. In recent years several approaches have been developed to reprogram the immune response by targeting molecules involved in the immune synapse. Monoclonal antibodies, such as those targeting the lymphocyte co-receptor, costimulatory and adhesion molecules (CD3, CD4, CD40L, CTLA4-Ig, LFA-1), or altered peptide ligands have been shown capable of inducing immune tolerance in transplantation, autoimmunity and allergy. This volume discusses the progress in the field, from basic science to clinical trials, and the major mechanisms involved. It is of interest to clinicians and researchers working in this area.
format Digital
author Graca, Luis.
SpringerLink (Online service)
author_facet Graca, Luis.
SpringerLink (Online service)
author_sort Graca, Luis.
title The Immune Synapse as a Novel Target for Therapy
title_short The Immune Synapse as a Novel Target for Therapy
title_full The Immune Synapse as a Novel Target for Therapy
title_fullStr The Immune Synapse as a Novel Target for Therapy
title_full_unstemmed The Immune Synapse as a Novel Target for Therapy
title_sort immune synapse as a novel target for therapy
publishDate 2022
url http://dx.doi.org/10.1007/978-3-7643-8296-4
work_keys_str_mv AT gracaluis theimmunesynapseasanoveltargetfortherapy
AT springerlinkonlineservice theimmunesynapseasanoveltargetfortherapy
AT gracaluis immunesynapseasanoveltargetfortherapy
AT springerlinkonlineservice immunesynapseasanoveltargetfortherapy
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