Inhibitory Regulation of Excitatory Neurotransmission

Within the central and peripheral nervous systems of animals, including man, inhibition is crucial to counterbalance excitatory neurotransmission, which is predominantly mediated by glutamate and its receptors. Although, particularly in brain, much of this inhibition is provided by classical post-sy...

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Principais autores: Darlison, Mark G., SpringerLink (Online service)
Formato: Digital
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Assuntos:
Neurociências.
Bioquímica.
Citologia.
Ciências da vida.
Endereço do item:http://dx.doi.org/10.1007/978-3-540-72602-9
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spelling oai:localhost:123456789-1300402023-07-17T15:09:01Z Inhibitory Regulation of Excitatory Neurotransmission Darlison, Mark G. SpringerLink (Online service) Neurociências. Bioquímica. Citologia. Ciências da vida. Within the central and peripheral nervous systems of animals, including man, inhibition is crucial to counterbalance excitatory neurotransmission, which is predominantly mediated by glutamate and its receptors. Although, particularly in brain, much of this inhibition is provided by classical post-synaptic GABAA receptors, many other proteins and mechanisms regulate excitation. These exist both to "fine tune" neurotransmission and to prevent overexcitation that could lead to conditions such as epilepsy and excitotoxicity, which can result in cell death. This book reviews aspects of GABAA receptor function, as well as the properties of a variety of other important inhibitory proteins, such as GABAC receptors, G-protein coupled receptors (specifically, GABAB receptors, metabotropic glutamate receptors and neuropeptide receptors), glycine receptors, GABA transporters and potassium channels. In addition, the consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are discussed. 0 2022-10-06T07:57:28Z 2022-10-06T07:57:28Z 2008. Digital 612.8 D221i 9783540726029 198477 http://dx.doi.org/10.1007/978-3-540-72602-9 http://dx.doi.org/10.1007/978-3-540-72602-9
institution Acervo SISBI
collection SIGAA
topic Neurociências.
Bioquímica.
Citologia.
Ciências da vida.
spellingShingle Neurociências.
Bioquímica.
Citologia.
Ciências da vida.
Darlison, Mark G.
SpringerLink (Online service)
Inhibitory Regulation of Excitatory Neurotransmission
description Within the central and peripheral nervous systems of animals, including man, inhibition is crucial to counterbalance excitatory neurotransmission, which is predominantly mediated by glutamate and its receptors. Although, particularly in brain, much of this inhibition is provided by classical post-synaptic GABAA receptors, many other proteins and mechanisms regulate excitation. These exist both to "fine tune" neurotransmission and to prevent overexcitation that could lead to conditions such as epilepsy and excitotoxicity, which can result in cell death. This book reviews aspects of GABAA receptor function, as well as the properties of a variety of other important inhibitory proteins, such as GABAC receptors, G-protein coupled receptors (specifically, GABAB receptors, metabotropic glutamate receptors and neuropeptide receptors), glycine receptors, GABA transporters and potassium channels. In addition, the consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are discussed.
format Digital
author Darlison, Mark G.
SpringerLink (Online service)
author_facet Darlison, Mark G.
SpringerLink (Online service)
author_sort Darlison, Mark G.
title Inhibitory Regulation of Excitatory Neurotransmission
title_short Inhibitory Regulation of Excitatory Neurotransmission
title_full Inhibitory Regulation of Excitatory Neurotransmission
title_fullStr Inhibitory Regulation of Excitatory Neurotransmission
title_full_unstemmed Inhibitory Regulation of Excitatory Neurotransmission
title_sort inhibitory regulation of excitatory neurotransmission
publishDate 2022
url http://dx.doi.org/10.1007/978-3-540-72602-9
work_keys_str_mv AT darlisonmarkg inhibitoryregulationofexcitatoryneurotransmission
AT springerlinkonlineservice inhibitoryregulationofexcitatoryneurotransmission
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